ANAPC7 - anaphase promoting complex subunit 7 Gene

Homo sapiens

Also known as APC7; FERBON

Gene ID: 51434 | Gene type: protein coding

About ANAPC7

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,372,900-110,403,708 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 11.7), esophagus (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin Ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

ANAPC7 Products(7)

mRNA	Protein	Name
NM_001137664.2	NP_001131136.2	anaphase-promoting complex subunit 7 isoform b
NM_001385208.1	NP_001372137.1	anaphase-promoting complex subunit 7 isoform c precursor
NM_001385209.1	NP_001372138.1	anaphase-promoting complex subunit 7 isoform d
NM_001385210.1	NP_001372139.1	anaphase-promoting complex subunit 7 isoform d
NM_001385211.1	NP_001372140.1	anaphase-promoting complex subunit 7 isoform e
NM_001385212.1	NP_001372141.1	anaphase-promoting complex subunit 7 isoform f
NM_016238.3	NP_057322.3	anaphase-promoting complex subunit 7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme-substrate adaptor activity	IDA IDA: Inferred from direct assay	34942119	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	21241890	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in brain development	IMP IMP: Inferred from mutant phenotype	34942119	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	34942119	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	16364912	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA
located in heterochromatin	IMP IMP: Inferred from mutant phenotype	34942119	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	18445686	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18445686	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC7 Protein Structure

TPR_11

TPR_2

0
100
200
300
400
500
599 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit 7

cyclosome subunit 7

Related Diseases

Diseases

Alias

Ferguson-Bonni Neurodevelopmental Syndrome

FERBON

B-Lymphoblastic Leukemia/Lymphoma With Tcf3-Pbx1

B Acute Lymphoblastic Leukemia With T(1	19)(Q23
P13.3)	E2a-Pbx1 (Tcf3-Pbx1)
B-All With Tcf3-Pbx1	B-Lymphoblastic Leukemia/Lymphoma With T(1
19)(Q23	P13.3)
Tcf3-Pbx1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00683	ANAPC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ANAPC7	VGNC	VGNC:59777
Macaca mulatta	ANAPC7	VGNC	VGNC:108286
Mus musculus	ANAPC7	MGD	MGI:1929711
Canis familiaris	ANAPC7	VGNC	VGNC:52919
Rattus norvegicus	ANAPC7	RGD	RGD:1311927
Bos taurus	ANAPC7	VGNC	VGNC:53888

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