2. Gene
  3. PRRX2 - paired related homeobox 2 Gene

PRRX2 - paired related homeobox 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PMX2; PRX2

Gene ID: 51450 | Gene type: protein coding

About PRRX2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,665,647-129,722,674 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 50 paralogues. Broad expression in skin (RPKM 3.1), prostate (RPKM 3.0) and 17 other tissues.

Summary

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]

PRRX2 Products(1)

mRNA Protein Name
NM_016307.4 NP_057391.1 paired mesoderm homeobox protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRRX2 Protein Structure

Homeobox

Homeobox: Homeobox domain (105 - 161)

OAR

OAR: OAR domain (227 - 245)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

paired mesoderm homeobox protein 2

PRX-2

Related Diseases

Diseases Alias
Agnathia-Otocephaly Complex

Otocephaly

Holoprosencephaly-Agnathia

Dysgnathia Complex Agnathia-Holoprosencephaly

AGOTC

Agnathia-Holoprosencephaly-Situs Inversus Syndrome

Dysgnathia Complex

Agnathia-Holoprosencephaly

Cervical Auricle
Hypoplastic Right Heart Syndrome

Right Hypoplastic Heart Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11244 PRRX2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRRX2 MGD MGI:98218
Canis familiaris PRRX2 VGNC VGNC:49775
Rattus norvegicus PRRX2 RGD RGD:1311471
Bos taurus PRRX2 VGNC VGNC:58400
Felis catus PRRX2 VGNC VGNC:64396