PDE7A - phosphodiesterase 7A Gene

Homo sapiens

Also known as HCP1; PDE7

Gene ID: 5150 | Gene type: protein coding

About PDE7A

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:65,714,334-65,842,064 (from NCBI)

This gene has 8 transcripts (splice variants), 240 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 14.6), appendix (RPKM 7.7) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

PDE7A Products(5)

mRNA	Protein	Name
NM_002603.4	NP_002594.1	high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform a precursor
NM_001242318.3	NP_001229247.1	high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c
NM_002604.2
XM_011517540.4	XP_011515842.1	high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1
XM_017013538.3	XP_016869027.1	high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	8389765	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	9195912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE7A Protein Structure

PDEase_I

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

TM22	high affinity cAMP-specific PDE 1
phosphodiesterase isozyme 7

Related Diseases

Diseases

Alias

Low Compliance Bladder

Overactive Bladder	Hyperactivity Of Bladder
Hypertonic Bladder	Hypertonicity Of Bladder
Low Bladder Compliance	Oab - [Overactive Bladder]

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Microphthalmia, Isolated 1

Isolated Microphthalmia 1	MCOP1
Mcop	Anophthalmia, Clinical, Isolated
Microphthalmos, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112831	Osoresnontrine	Inhibitor	99.88%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109586	BRL-50481	Inhibitor	99.85%	Unkown
HY-146201	PDE4B/7A-IN-1		/	Unkown
HY-146202	PDE4B/7A-IN-2		/	Unkown
HY-RS10238	PDE7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10239	Pde7a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10240	Pde7a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDE7A	VGNC	VGNC:68764
Rattus norvegicus	PDE7A	RGD	RGD:68391
Mus musculus	PDE7A	MGD	MGI:1202402
Bos taurus	PDE7A	VGNC	VGNC:32685
Macaca mulatta	PDE7A	VGNC	VGNC:75922
Canis familiaris	PDE7A	VGNC	VGNC:44363
Others	PDE7A	NCBI

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