CXXC5 - CXXC finger protein 5 Gene

Homo sapiens

Also known as CF5; WID; RINF; HSPC195

Gene ID: 51523 | Gene type: protein coding

About CXXC5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,647,299-139,683,882 (from NCBI)

This gene has 16 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues.

Summary

The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

CXXC5 Products(14)

mRNA	Protein	Name
NM_001317199.2	NP_001304128.1	CXXC-type zinc finger protein 5
NM_001317200.2	NP_001304129.1	CXXC-type zinc finger protein 5
NM_001317201.2	NP_001304130.1	CXXC-type zinc finger protein 5
NM_001317202.2	NP_001304131.1	CXXC-type zinc finger protein 5
NM_001317203.2	NP_001304132.1	CXXC-type zinc finger protein 5
NM_001317204.2	NP_001304133.1	CXXC-type zinc finger protein 5
NM_001317205.2	NP_001304134.1	CXXC-type zinc finger protein 5
NM_001317206.2	NP_001304135.1	CXXC-type zinc finger protein 5
NM_001317207.2	NP_001304136.1	CXXC-type zinc finger protein 5
NM_001317208.2	NP_001304137.1	CXXC-type zinc finger protein 5
NM_001317209.2	NP_001304138.1	CXXC-type zinc finger protein 5
NM_001317210.2	NP_001304139.1	CXXC-type zinc finger protein 5
NM_001317211.2	NP_001304140.1	CXXC-type zinc finger protein 5
NM_016463.9	NP_057547.5	CXXC-type zinc finger protein 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	23303788	GOA
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	29276034	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23303788	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29276034	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23303788	GOA
involved in regulation of generation of precursor metabolites and energy	IDA IDA: Inferred from direct assay	23303788	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXXC5 Protein Structure

zf-CXXC

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

CXXC-type zinc finger protein 5

CXXC finger 5 protein

Related Diseases

Diseases

Alias

Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration

Arthrogryposis, Distal, Type 4

Distal Arthrogryposis Type 4	DA4
Daiid	Arthrogryposis-Severe Scoliosis Syndrome
Distal Arthrogryposis Type Iid	Arthrogryposis With Severe Scoliosis
Arthrogryposis, Distal, Type Iid

Astroblastoma

Cerebral Astroblastoma

Cardiomyopathy, Familial Hypertrophic, 17

Hypertrophic Cardiomyopathy 17	CMH17
Cardiomyopathy, Hypertrophic, 17	Cardiomyopathy Familial Hypertrophic 17
Cardiomyopathy, Familial Hypertrophic 17	Cardiomyopathy, Hypertrophic, Familial, Type 17

Spondyloepiphyseal Dysplasia, Kimberley Type

SEDK	Spondyloepiphyseal Dysplasia Kimberley Type
Spondyloepiphyseal Dysplasia Type Kimberley	Dysplasia, Spondyloepiphyseal, Kimberley Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131447	KY19382		≥98.0%	Unkown
HY-124156A	KY-02327 acetate	Inhibitor	99.35%	Unkown
HY-131448	A3334	Inhibitor	99.64%	Unkown
HY-124156	KY-02327	Inhibitor	/	Unkown
HY-RS03415	CXXC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXXC5	VGNC	VGNC:71594
Canis familiaris	CXXC5	VGNC	VGNC:39754
Bos taurus	CXXC5	VGNC	VGNC:27860
Felis catus	CXXC5	VGNC	VGNC:61305
Rattus norvegicus	CXXC5	RGD	RGD:1359466
Mus musculus	CXXC5	MGD	MGI:1914643

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