ZC3HC1 - zinc finger C3HC-type containing 1 Gene

Homo sapiens

Also known as NIPA; HSPC216

Gene ID: 51530 | Gene type: protein coding

About ZC3HC1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,018,286-130,051,451 (from NCBI)

This gene has 12 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 2.0) and 25 other tissues.

Summary

This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin Ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin Ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]

ZC3HC1 Products(4)

mRNA	Protein	Name
NM_001282190.2	NP_001269119.1	zinc finger C3HC-type protein 1 isoform 2
NM_001282191.1	NP_001269120.1	zinc finger C3HC-type protein 1 isoform 3
NM_001363701.1	NP_001350630.1	zinc finger C3HC-type protein 1 isoform 4
NM_016478.5	NP_057562.3	zinc finger C3HC-type protein 1 isoform 1

ZC3HC1 Protein Structure

zf-C3HC

Rsm1

0
100
200
300
400
502 a.a.

Protein Preferred Names

Protein Names

zinc finger C3HC-type protein 1

nuclear-interacting partner of ALK

hematopoietic stem/progenitor cell protein 216

Related Diseases

Diseases

Alias

Immunodeficiency 30

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency	IMD30
Il12rb1 Deficiency	Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency
Msmd Due To Complete Il12rb1 Deficiency	Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency
Il-12râ1 Deficiency	Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency
Immunodeficiency, Type 30

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15998	ZC3HC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZC3HC1	MGD	MGI:1916023
Felis catus	ZC3HC1	VGNC	VGNC:67192
Macaca mulatta	ZC3HC1	VGNC	VGNC:79827
Rattus norvegicus	ZC3HC1	RGD	RGD:1561099
Bos taurus	ZC3HC1	VGNC	VGNC:37113

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