SLC25A39 - solute carrier family 25 member 39 Gene

Homo sapiens

Also known as CGI69; CGI-69

Gene ID: 51629 | Gene type: protein coding

About SLC25A39

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,319,628-44,324,823 (from NCBI)

This gene has 17 transcripts (splice variants), 143 orthologues and 49 paralogues. Ubiquitous expression in bone marrow (RPKM 112.9), kidney (RPKM 47.3) and 25 other tissues.

Summary

This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to Other carriers known to transport Amino acids. This protein may play a role in iron homeostasis. [provided by RefSeq, Mar 2016]

SLC25A39 Products(5)

mRNA	Protein	Name
NM_001143780.3	NP_001137252.1	probable mitochondrial glutathione transporter SLC25A39 isoform a
NM_001321240.2	NP_001308169.1	probable mitochondrial glutathione transporter SLC25A39 isoform c
NM_001321241.2	NP_001308170.1	probable mitochondrial glutathione transporter SLC25A39 isoform d
NM_001366726.1	NP_001353655.1	probable mitochondrial glutathione transporter SLC25A39 isoform e
NM_016016.4	NP_057100.1	probable mitochondrial glutathione transporter SLC25A39 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2 iron, 2 sulfur cluster binding	IDA IDA: Inferred from direct assay	37917749	GOA
enables glutathione transmembrane transporter activity	IDA IDA: Inferred from direct assay	34707288	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to iron ion	IDA IDA: Inferred from direct assay	37917749	GOA
involved in glutathione import into mitochondrion	IDA IDA: Inferred from direct assay	34707288	GOA
involved in glutathione import into mitochondrion	IMP IMP: Inferred from mutant phenotype	35513392	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	11256614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A39 Protein Structure

Mito_carr

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

probable mitochondrial glutathione transporter SLC25A39

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 18

Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome	COXPD18
Combined Oxidative Phosphorylation Deficiency, Type 18

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13121	SLC25A39 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC25A39	VGNC	VGNC:34764
Canis familiaris	SLC25A39	VGNC	VGNC:49801
Rattus norvegicus	SLC25A39	RGD	RGD:1306193
Mus musculus	SLC25A39	MGD	MGI:1196386
Felis catus	SLC25A39	VGNC	VGNC:65274
Macaca mulatta	SLC25A39	VGNC	VGNC:77568

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