2. Gene
  3. PALS2 - protein associated with LIN7 2, MAGUK p55 family member Gene

PALS2 - protein associated with LIN7 2, MAGUK p55 family member Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MPP6; VAM1; p55T; VAM-1

Gene ID: 51678 | Gene type: protein coding

About PALS2

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:24,573,452-24,694,193 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in gall bladder (RPKM 5.7), testis (RPKM 4.9) and 23 other tissues.

Summary

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]

PALS2 Products(2)

mRNA Protein Name
NM_001303037.2 NP_001289966.1 protein PALS2
NM_016447.4 NP_057531.2 protein PALS2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11311936 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALS2 Protein Structure

L27

L27: L27 domain (1 - 54)

L27

L27: L27 domain (57 - 108)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (134 - 206)

SH3_2

SH3_2: Variant SH3 domain (219 - 281)

Guanylate_kin

Guanylate_kin: Guanylate kinase (337 - 526)

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  • 540 a.a.
Protein Preferred Names Protein Names

protein PALS2

MAGUK p55 subfamily member 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10010 PALS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PALS2 VGNC VGNC:31585
Felis catus PALS2 VGNC VGNC:80627
Rattus norvegicus PALS2 RGD RGD:1311833
Mus musculus PALS2 MGD MGI:1927340
Macaca mulatta PALS2 VGNC VGNC:74790
Canis familiaris PALS2 VGNC VGNC:43347