LUC7L3 - LUC7 like 3 pre-mRNA splicing factor Gene

Homo sapiens

Also known as CRA; CROP; LUC7A; hLuc7A; CREAP-1; OA48-18

Gene ID: 51747 | Gene type: protein coding

About LUC7L3

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,719,603-50,756,219 (from NCBI)

This gene has 23 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 53.0), ovary (RPKM 46.4) and 25 other tissues.

Summary

This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

LUC7L3 Products(3)

mRNA	Protein	Name
NM_001330330.2	NP_001317259.1	luc7-like protein 3 isoform 2
NM_006107.4	NP_006098.2	luc7-like protein 3 isoform 1
NM_016424.5	NP_057508.2	luc7-like protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IMP IMP: Inferred from mutant phenotype	10631324	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15798186	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	10631324	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12565863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LUC7L3 Protein Structure

LUC7

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

luc7-like protein 3

CRE-associated protein 1

Related Diseases

Diseases

Alias

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07890	LUC7L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LUC7L3	VGNC	VGNC:42864
Mus musculus	LUC7L3	MGD	MGI:1914934
Rattus norvegicus	LUC7L3	RGD	RGD:1307981
Felis catus	LUC7L3	VGNC	VGNC:63328
Macaca mulatta	LUC7L3	VGNC	VGNC:74346
Bos taurus	LUC7L3	VGNC	VGNC:31080

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