SIX4 - SIX homeobox 4 Gene

Homo sapiens

Also known as AREC3

Gene ID: 51804 | Gene type: protein coding

About SIX4

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,709,539-60,724,351 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 6 paralogues. Broad expression in prostate (RPKM 2.0), salivary gland (RPKM 1.8) and 16 other tissues.

Summary

This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]

SIX4 Products(1)

mRNA	Protein	Name
NM_017420.5	NP_059116.3	homeobox protein SIX4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIX4 Protein Structure

Homeobox

0
200
400
600
781 a.a.

Protein Preferred Names

Protein Names

homeobox protein SIX4

sine oculis homeobox homolog 4

Related Diseases

Diseases

Alias

Branchiootic Syndrome

Bo Syndrome	Branchiootic Dysplasia
Bor	Bo Syndrome 1
Bos1	Branchiootic Syndrome 1

Bardet-Biedl Syndrome 8

BBS8	Bardet-Biedl Syndrome, Type 8

Branchiootorenal Syndrome

Branchio-Oto-Renal Syndrome	Bor Syndrome
Branchiootorenal Dysplasia	Melnick-Fraser Syndrome
Branchiootorenal Spectrum Disorders	Branchio-Otorenal Dysplasia
Branchio Oto Renal Syndrome	Branchiootorenal/Branchiootic Syndrome
Bo Syndrome	Bor
Bos	Branchio-Otorenal Syndrome
Branchiootic Syndrome	Branchiootorenal Syndrome
Branchiootic Syndrome 1

Paralytic Squint

Paralytic Strabismus

Incomitant Dissociation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12961	SIX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SIX4	VGNC	VGNC:46192
Mus musculus	SIX4	MGD	MGI:106034
Felis catus	SIX4	VGNC	VGNC:80845
Macaca mulatta	SIX4	VGNC	VGNC:99240
Bos taurus	SIX4	VGNC	VGNC:109396
Rattus norvegicus	SIX4	RGD	RGD:1306726

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