CALML5 - calmodulin like 5 Gene

Homo sapiens

Also known as CLSP

Gene ID: 51806 | Gene type: protein coding

About CALML5

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,498,697-5,499,570 (from NCBI)

This gene has 1 transcript (splice variant), 239 orthologues and 20 paralogues.

Summary

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the Calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key Enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]

CALML5 Products(1)

mRNA	Protein	Name
NM_017422.5	NP_059118.2	calmodulin-like protein 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALML5 Protein Structure

EF-hand_7

0
100
146 a.a.

Protein Preferred Names

Protein Names

calmodulin-like protein 5

calmodulin-like skin protein

Recombinant CALML5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76760	CALML5 Protein, Human (His)	Q9NZT1 (M1-E146)	≥95%

Related Diseases

Diseases

Alias

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01845	CALML5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CALML5	VGNC	VGNC:56179
Mus musculus	CALML5	MGD	MGI:1931464
Rattus norvegicus	CALML5	RGD	RGD:1310047
Macaca mulatta	CALML5	VGNC	VGNC:70576
Canis familiaris	CALML5	VGNC	VGNC:38672
Others	CALML5	NCBI

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