PF4V1 - platelet factor 4 variant 1 Gene

Homo sapiens

Also known as PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1

Gene ID: 5197 | Gene type: protein coding

About PF4V1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,853,296-73,854,483 (from NCBI)

This gene has 1 transcript (splice variant), 25 orthologues and 12 paralogues. Biased expression in bone marrow (RPKM 2.7), spleen (RPKM 1.4) and 9 other tissues.

Summary

The protein encoded by this gene is a chemokine that is highly similar to Platelet Factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]

PF4V1 Products(1)

mRNA	Protein	Name
NM_002620.4	NP_002611.1	platelet factor 4 variant precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PF4V1 Protein Structure

IL8

0
104 a.a.

Protein Preferred Names

Protein Names

platelet factor 4 variant

C-X-C motif chemokine 4

PF4V1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PF4V1	P10720	XCL1	Homo sapiens	P47992	Filter Binding	28381538
Intra	PF4V1	P10720	CXCL11	Homo sapiens	O14625	Filter Binding	28381538
Intra	PF4V1	P10720	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	PF4V1	P10720	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	PF4V1	P10720	CCL25	Homo sapiens	O15444	Filter Binding	28381538
Intra	PF4V1	P10720	CCL21	Homo sapiens	O00585	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PF4V1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76539	PF4V1 Protein, Human (HEK293, Fc)	NP_002611.1 (F31-S104)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10356	PF4V1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PF4V1	MGD	MGI:1888711
Macaca mulatta	PF4V1	VGNC	VGNC:75954
Others	PF4V1	NCBI

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