2. Gene
  3. PIGF - phosphatidylinositol glycan anchor biosynthesis class F Gene

PIGF - phosphatidylinositol glycan anchor biosynthesis class F Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OORS

Gene ID: 5281 | Gene type: protein coding

About PIGF

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,580,937-46,617,041 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 42.1), heart (RPKM 35.0) and 25 other tissues.

Summary

This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

PIGF Products(2)

mRNA Protein Name
NM_002643.4 NP_002634.1 phosphatidylinositol-glycan biosynthesis class F protein isoform 1
NM_173074.3 NP_775097.1 phosphatidylinositol-glycan biosynthesis class F protein isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in GPI anchor biosynthetic process IMP
IMP: Inferred from mutant phenotype
33386993 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIGF Protein Structure

PIG-F

PIG-F: GPI biosynthesis protein family Pig-F (13 - 206)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol-glycan biosynthesis class F protein

GPI11 homolog

PIGF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
PIGF Q07326 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
Intra
PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
Intra
PIGF Q07326 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
PIGF Q07326 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
PIGF Q07326 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra
PIGF Q07326 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Onychodystrophy, Osteodystrophy, Impaired Intellectual Development, And Seizures Syndrome

OORS

Oors Syndrome

Glycosylphosphatidylinositol Biosynthesis Defect 24

Gpibd24
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10831 GNQWFI Antagonist / Unkown
HY-RS10490 PIGF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PIGF MGD MGI:99462
Canis familiaris PIGF VGNC VGNC:44532
Bos taurus PIGF VGNC VGNC:32868
Felis catus PIGF VGNC VGNC:81148
Rattus norvegicus PIGF RGD RGD:1584658
Macaca mulatta PIGF VGNC VGNC:81499