PIK3C2A - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Gene

Homo sapiens

Also known as CPK; OCSKD; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PI3-K-C2(ALPHA)

Gene ID: 5286 | Gene type: protein coding

About PIK3C2A

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,086,575-17,207,986 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 18.0), testis (RPKM 13.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by Insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

PIK3C2A Products(6)

mRNA	Protein	Name
NM_001321378.2	NP_001308307.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1
XM_047427128.1	XP_047283084.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2
NM_001321380.2	NP_001308309.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 2
NM_002645.4	NP_002636.2	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1
XM_047427127.1	XP_047283083.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1
NM_001386870.1	NP_001373799.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	9337861	GOA
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	9337861	GOA
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA IDA: Inferred from direct assay	9337861	GOA
enables clathrin binding	IDA IDA: Inferred from direct assay	11239472	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21081650	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	28910396	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	26175229	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	10766823	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21081650	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10766823	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10766823	GOA
located in vesicle	IDA IDA: Inferred from direct assay	21081650	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C2A Protein Structure

PI3K_rbd

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
300
600
900
1200
1500
1686 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

C2-containing phosphatidylinositol kinase	phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
phosphoinositide 3-kinase-C2-alpha	phosphoinositide-3-kinase, class 2, alpha polypeptide
ptdIns-3-kinase C2 subunit alpha

Related Diseases

Diseases

Alias

Acute Anterolateral Myocardial Infarction

Acute Myocardial Infarction Of Anterolateral Wall

Muscular Dystrophy, Duchenne Type

Duchenne Muscular Dystrophy	DMD
Muscular Dystrophy, Duchenne	Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type
Severe Dystrophinopathy, Duchenne Type	Muscular Dystrophy Duchenne
Dystrophy, Muscular, Duchenne Type	Benign Duchenne Muscular Dystrophy
Duchenne Motor Neuron Disease	Duchenne Type Dystrophy
Duchenne-Griesinger Disease

Endocarditis

Necrotizing Fasciitis

Fasciitis, Necrotizing

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Exanthem

Exanthema	Rash
Rashes

Pyomyositis

Tropical Pyomyositis	Myositis Purulenta Tropica
Myositis Tropicans	Pm
Suppurative Myositis	Purulent Myositis

Gas Gangrene

Myonecrosis	Gas Bacillus Infection
Gas Gangrene Due To Clostridia	Clostridial Myonecrosis
Clostridial Cellulitis

Muscular Lipidosis

Lipid Storage Myopathy

Posteroinferior Myocardial Infarction

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Miyoshi Muscular Dystrophy

Distal Myopathy	Distal Muscular Dystrophy
Miyoshi Myopathy	Distal Myopathies
Dystrophy, Muscular, Miyoshi	Myopathy, Distal
Distal Muscular Dystrophies

Hemopneumothorax

Haemopneumothorax

Muscle Tissue Disease

Quadriplegia

Tetraplegia

Tetraplegias

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Extrinsic Cardiomyopathy

Inflammatory And Toxic Neuropathy

Erysipelas

Compartment Syndrome

Compartment Syndromes

Compartmental Syndrome

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Sarcoid Meningitis

Meningitis In Sarcoidosis

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Rectum Neuroendocrine Neoplasm

Neuroendocrine Tumor Of Rectum	Neuroendocrine Tumor Of The Rectum
Net Of The Rectum	Rectal Net
Rectal Neuroendocrine Tumor	Rectal Neuroendocrine Neoplasm

Myopathy

Muscular Diseases

Myopathies

Aspiration Pneumonia

Pneumonia, Aspiration	Pneumonia Aspiration
Aspiration Pneumonitis

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Hypokalemia

Potassium Deficiency	Potassium Deficiency Disorder
Hypopotassemia	Potassium
Potassium [K] Deficiency	Hypokalaemic Syndrome
Hypopotassaemia	Hypopotassaemia Syndrome
Hypokalaemic	Potassium Depletion

Disseminated Intravascular Coagulation

Defibrination Syndrome	Dic
Diffuse Or Disseminated Intravascular Coagulation	Fibrinolytic Purpura
Consumption Coagulopathy	Diffuse Intravascular Coagulation
Dic - [Disseminated Intravascular Coagulation]	Disseminated Intravascular Coagulopathy
Fibrinolysis Nos	Thrombolytic Purpura

Muscular Dystrophy, Becker Type

Becker Muscular Dystrophy	BMD
Benign Pseudohypertrophic Muscular Dystrophy	Benign Congenital Myopathy
Becker Dystrophinopathy	Becker'S Muscular Dystrophy
Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type	Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type
Muscular Dystrophy Becker	Dystrophy, Muscular, Becker Type
Dystrophinopathy	Becker Dystrophy
Becker Type Dystrophy	Bmd - [Becker Muscular Dystrophy]

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Muscular Disease

Dermatomyositis

Amyopathic Dermatomyositis	Dermatopolymyositis
Adult Dermatomyositis	Polymyositis With Skin Involvement
Adult Type Dermatomyositis	Petges-Clejat Syndrome

Posterior Myocardial Infarction

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Toxoplasmosis

Disseminated Toxoplasmosis	Multisystemic Disseminated Toxoplasmosis
Acquired Toxoplasmosis	Toxoplasmosis Disease Or Disorder
Infection By Toxoplasma Gondii	Toxoplasmal
Toxoplasma

Myringitis Bullosa Hemorrhagica

Bullous Myringitis

Cutis Laxa, Autosomal Recessive, Type Iiia

ARCL3A	De Barsy Syndrome A
Aldh18a1-Related De Barsy Syndrome	Progeroid Syndrome Of De Barsy
Autosomal Recessive Cutis Laxa Type Iiia	P5cs Deficiency
De Barsy Syndrome	Cutis Laxa, Corneal Clouding, And Mental Retardation
Delta-1-Pyrroline 5-Carboxylate Synthetase Deficiency	Neurocutaneous Syndrome, Bicknell Type
Cutis Laxa Corneal Clouding Mental Retardation	Progeroid Syndrome De Barsy Type
Cutis Laxa, Autosomal Recessive, 3a	Cutis Laxa Autosomal Recessive Type Iiia
Developmental Delay-Choreoathetosis-Joint Dislocation-Lax Skin	Neurocutaneous Syndrome Bicknell Type
Corneal Clouding Cutis Laxa Mental Retardation

Osteogenesis Imperfecta, Type Xviii

OI18	Osteogenesis Imperfecta Type 18
Osteogenesis Imperfecta, Type 18	Osteogenesis Imperfecta 18

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Toxic Myocarditis

Anterior Compartment Syndrome

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Neuroleptic Malignant Syndrome

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Myotonic Dystrophy 1

Myotonic Dystrophy	Dystrophia Myotonica
Steinert Disease	Myotonic Dystrophy Type 1
Myotonia Atrophica	DM1
Congenital Myotonic Dystrophy	Myotonia Dystrophica
Steinert Myotonic Dystrophy	Dystrophia Myotonica 1
Dm	Steinert'S Disease
Steinert Myotonic Dystrophy Syndrome	Myotonic Dystrophy Of Steinert
Dystrophia Myotonica Type 1	Myotonic Dystrophy Congenital
Dystrophy, Myotonic, Type 1	Dm - [Dystrophia Myotonica]
Myotonic Muscular Dystrophy

Dengue Disease

Dengue Fever	Dengue
Df	Dengue Shock Syndrome
Dengue Virus Infection	Breakbone Fever
Classic Dengue	Classical Dengue
Dengue Hemorrhagic Fever	Hemorrhagic Dengue
Philippine Hemorrhagic Fever	Singapore Hemorrhagic Fever
Thai Hemorrhagic Fever	Severe Dengue
Dengue Fever Without Warning Signs	Dengue Haemorrhagic Fever Grade 1
Dengue Haemorrhagic Fever Without Warning Signs	Bangkok Haemorrhagic Fever
Singapore Haemorrhagic Fever	Thailand Haemorrhagic Fever
Southeast Asia Haemorrhagic Fever	Dhf -[Dengue Haemorrhagic Fever]
Dengue Fever With Warning Signs	Dengue Haemorrhagic Fever With Warning Signs
Dengue Haemorrhagic Fever Grade 2	Philippine Haemorrhagic Fever

Spastic Paraplegia 9b, Autosomal Recessive

SPG9B	Autosomal Recessive Complex Spastic Paraplegia Type 9b
Hereditary Spastic Paraplegia 9b	Autosomal Recessive Spastic Paraplegia 9b
Autosomal Recessive Spastic Paraplegia Type 9b	Ar-Spg9b

Metabolic Acidosis

Left Bundle Branch Hemiblock

Left Bundle Branch Block

Left Bundle-Branch Block

Angina Pectoris

Prinzmetal'S Variant Angina	Prinzmetal Angina
Variant Angina	Angina
Angina Inversa	Prinzmetal'S Angina
Coronary Artery Vasospasm	Angina Pectoris, Variant
Variant Angina Pectoris	Vasospastic Angina
Angor Pectoris	Anginal Syndrome
Ischaemic Chest Pain	Angina Pectoris Syndrome
Angina Syndrome	Cardiac Angina Syndrome
Ap - [Angina Pectoris]	Angina Nos
Ap - [Angina Pectoris] Syndrome	Ischaemic Heart Disease With Angina
Heart Angina	Chest Angina
Angina Attack	Anginal Cardiopathy
Coronary Pain Nos

Exophthalmic Ophthalmoplegia

Coronary Stenosis

Coronary Artery Stenosis

Sarcocystosis

Sarcosporidiosis

Sarcosporidiasis

Crimean-Congo Hemorrhagic Fever

Crimean Hemorrhagic Fever	Cchf
Congo Hemorrhagic Fever	Hemorrhagic Fever, Crimean
Chf Congo Virus	Congo-Crimean Hemorrhagic Fever
Congo Fever	Hemorrhagic Fever Crimean-Congo
Cchf - [Crimean-Congo Haemorrhagic Fever]	Kara Mikh Typhoid Fever
Xīnjiāng Haemorrhagic Fever

Pericardium Disease

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

Lateral Myocardial Infarction

Mutism

Myoglobinuria

Myxedema

Speech Disorder

Speech Disorders

Echolalia

Pulmonary Edema

Anteroseptal Myocardial Infarction

Ornithosis

Psittacosis	Chlamydial Pneumonia
Chlamydia Psittaci Infection	Chlamydia Psittaci

Hypothyroidism

Thyroid Diseases	Thyroid Deficiency
Thyroid Insufficiency	Dysfunction Thyroid
Thyroid Disease	Thyroid Dysfunction

Acute Kidney Failure

Acute Renal Failure	Renal Failure Acute
Acute Kidney Injury	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Disease, Susceptibility To
Coronary Artery Anomaly	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Isolated Elevated Serum Creatine Phosphokinase Levels

Elevated Serum Cpk	Idiopathic Hyperckemia
Isolated Hyperckemia	Elevated Serum Creatine Phosphokinase
H-Ck	Idiopathic Persistent Elevation Of Serum Creatine Kinase

Cardiogenic Shock

Shock Cardiogenic

Shock, Cardiogenic

Granulomatous Myositis

Ischemia

Acute Coronary Syndrome

Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration	MECRCN
Rhabdomyolysis

Cardiac Tamponade

Pericardial Tamponade

Rose'S Tamponade

Diabetes Mellitus

Diabetes

Status Asthmaticus

Asthma With Status Asthmaticus

Severe Asthma Attack

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Bacterial Meningitis

Meningitis, Bacterial	Meningitis Bacterial
Bm - [Bacterial Meningitis]	Leptomeningitis Bacterial
Pachymeningitis Bacterial	Arachnoiditis Bacterial

Creatine Phosphokinase, Elevated Serum

Hyperckemia, Idiopathic	Cpk, Elevated Serum
Hyperckmia	HYPCK

Oculoskeletodental Syndrome

OCSKD	Cataracts, Early-Onset, With Skeletal And Dental Anomalies
Oculocerebrodental Syndrome	Oculo-Cerebro-Dental Syndrome

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Lung Mixed Small Cell And Squamous Cell Carcinoma

Combined Small And Large Cell Lung Cancer	Mixed Small Cell And Squamous Cell Carcinoma Of Lung
Small Cell And Large Cell Carcinoma Of The Lung	Small Cell And Squamous Cell Carcinoma Of The Lung

Polymyositis

Pm - [Polymyositis]

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Acute And Chronic Respiratory Failure	Respiratory Insufficiency/Failure
Chronic Respiratory Disease	Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Leptospirosis

Fort Bragg Fever	Weil Disease
Leptospirosis Icterohaemorrhagica	Nanukayami Fever
Canicola Fever	Hemorrhagic Jaundice
Mud Fever	Stuttgart Disease
Swamp Fever	Rat Catcher'S Yellows
Spirochetal Jaundice	Weil'S Disease
Cane-Cutter Fever	Icterohemorrhagic Fever
Rice-Field Fever	Swineherd'S Disease
Weil Syndrome	Nanukayami
Canine Leptospirosis	Equine Infectious Anemia
Leptospirosis Canicola	Fever Due To Leptospira Autumnalis
Gikiyami	Leptospira Interrogans Autumnalis Infection
Leptospira Interrogans Canicola Infection	Leptospira Interrogans Hebdomadis Infection
Leptospira Interrogans Pomona Infection	Nanukayami Disease
Pretibial Fever	Seven-Day Fever
Eia - [Equine Infectious Anaemia]	Leptospira Interrogans Infection

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Pericardial Effusion

Noninflammatory Pericardial Effusion

Pericardium Effusion

Subendocardial Myocardial Infarction

Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis

Atrioventricular Block

Av Block

Raynaud Disease

Raynaud'S Disease	Raynaud Phenomenon
Raynaud'S Syndrome	Raynaud'S
Cold Fingers, Hereditary	Raynaud'S Phenomenon
Raynaud'S Disease/Phenomenon	Raynauds Syndrome
Raynauds Phenomenon	Secondary Raynaud'S Phenomenon
Raynaud Syndrome

Acute Kidney Tubular Necrosis

Acute Tubular Necrosis	Acute Renal Failure With Tubular Necrosis
Acute Tubule Necrosis	Acute Renal Failure With Lesion Of Tubular Necrosis
Atn - Acute Tubular Necrosis	Tubular Necrosis Acute
Kidney Tubular Necrosis, Acute	Acute Renal Tubular Necrosis
Acute Tubular Nephrosis	Ischaemic Acute Tubular Necrosis
Ischaemic Tubular Necrosis	Kidney Tubular Necrosis
Lower Nephron Nephrosis	Necrotising Renal Oedema
Renal Tubular Necrosis	Toxic Tubular Necrosis
Tubular Kidney Necrosis	Tubular Necrosis Nos
Tubular Nephrosis

Critical Illness Polyneuropathy

Polyneuropathy, Critical Illness

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Anuria

Suppression Of Urinary Secretion

Inferior Myocardial Infarction

Inferior Wall Myocardial Infarction

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Pleural Lipoma

Lipoma Of Pleura

Trichinosis

Trichinellosis	Human Trichinellosis
Trichiniasis	Trichinella Spiralis Infection
Infection With Trichinella	Trichinelliasis
Trichinella Spiralis Infestation

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112608	CHMFL-PI3KD-317	Inhibitor	98.04%	Unkown
HY-RS10511	PIK3C2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10512	Pik3c2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10513	Pik3c2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIK3C2A	MGD	MGI:1203729
Felis catus	PIK3C2A	VGNC	VGNC:68850
Macaca mulatta	PIK3C2A	VGNC	VGNC:75992
Canis familiaris	PIK3C2A	VGNC	VGNC:44551
Rattus norvegicus	PIK3C2A	RGD	RGD:1310389
Bos taurus	PIK3C2A	VGNC	VGNC:106866