2. Gene
  3. PIK3C2G - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Gene

PIK3C2G - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PI3K-C2GAMMA; PI3K-C2-gamma

Gene ID: 5288 | Gene type: protein coding

About PIK3C2G

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:18,242,961-18,726,817 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 9 paralogues. Biased expression in stomach (RPKM 3.1), skin (RPKM 2.0) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

PIK3C2G Products(17)

mRNA Protein Name
XM_047429006.1 XP_047284962.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2
XM_011520697.3 XP_011518999.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X6
XM_017019471.2 XP_016874960.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
NM_001288772.2 NP_001275701.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 1
NM_004570.6 NP_004561.3 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 3
XM_011520701.3 XP_011519003.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X9
XR_931307.3
XM_017019478.3 XP_016874967.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X10
NM_001288774.2 NP_001275703.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 2
XM_017019473.3 XP_016874962.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
XM_047429009.1 XP_047284965.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X5
XM_047429010.1 XP_047284966.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X8
XM_047429005.1 XP_047284961.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2
XM_017019475.2 XP_016874964.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X7
XM_017019479.2 XP_016874968.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X11
XM_047429008.1 XP_047284964.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X4
XM_047429007.1 XP_047284963.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X3
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in modulation by host of viral process IMP
IMP: Inferred from mutant phenotype
19376974 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C2G Protein Structure

PI3K_rbd

PI3K_rbd: PI3-kinase family, ras-binding domain (282 - 364)

PI3K_C2

PI3K_C2: Phosphoinositide 3-kinase C2 (510 - 629)

PI3Ka

PI3Ka: Phosphoinositide 3-kinase family, accessory domain (PIK domain) (663 - 814)

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (917 - 1128)

PX

PX: PX domain (1206 - 1305)

  • 0
  • 300
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  • 1200
  • 1445 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

PTDINS-3-kinase C2 gamma

phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide

phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma

phosphoinositide-3-kinase, class 2, gamma polypeptide

Related Diseases

Diseases Alias
Viral Labyrinthitis

Epidemic Vertigo

Vestibular Neuronitis
Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia
Spermatogenic Failure 17

SPGF17

Male Infertility Due To Oocyte Activation Failure

Spermatogenic Failure, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10517 PIK3C2G Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10518 Pik3c2g Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10519 Pik3c2g Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PIK3C2G VGNC VGNC:75993
Felis catus PIK3C2G VGNC VGNC:68852
Bos taurus PIK3C2G VGNC VGNC:32887
Mus musculus PIK3C2G MGD MGI:1203730
Canis familiaris PIK3C2G VGNC VGNC:44553
Rattus norvegicus PIK3C2G RGD RGD:620231
Others PIK3C2G NCBI