PLA2G5 - phospholipase A2 group V Gene

Homo sapiens

Also known as FRFB; GV-PLA2; PLA2-10; hVPLA(2)

Gene ID: 5322 | Gene type: protein coding

About PLA2G5

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:20,028,408-20,091,911 (from NCBI)

This gene has 8 transcripts (splice variants), 116 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues.

Summary

This gene is a member of the secretory Phospholipase A2 family. It is located in a tightly-linked cluster of secretory Phospholipase A2 genes on chromosome 1. The encoded Enzyme catalyzes the hydrolysis of membrane Phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this Enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

PLA2G5 Products(1)

mRNA	Protein	Name
NM_000929.3	NP_000920.1	phospholipase A2 group V precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-independent phospholipase A2 activity	IDA IDA: Inferred from direct assay	23533611	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiolipin acyl-chain remodeling	IDA IDA: Inferred from direct assay	23533611	GOA
involved in leukotriene biosynthetic process	IDA IDA: Inferred from direct assay	20432503	GOA
involved in phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	23533611	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	22837859	GOA
involved in positive regulation of immune complex clearance by monocytes and macrophages	IDA IDA: Inferred from direct assay	20432503	GOA
involved in positive regulation of phospholipase activity	IDA IDA: Inferred from direct assay	22837859	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G5 Protein Structure

Phospholip_A2_1

0
100
138 a.a.

Protein Preferred Names

Protein Names

phospholipase A2 group V

Ca2+-dependent phospholipase A2

Related Diseases

Diseases

Alias

Fleck Retina, Familial Benign

FRFB	Familial Benign Flecked Retina
Familial Benign Fleck Retina

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10632	PLA2G5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLA2G5	VGNC	VGNC:32963
Felis catus	PLA2G5	VGNC	VGNC:68882
Mus musculus	PLA2G5	MGD	MGI:101899
Canis familiaris	PLA2G5	VGNC	VGNC:44630
Rattus norvegicus	PLA2G5	RGD	RGD:62051

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