PLAG1 - PLAG1 zinc finger Gene

Homo sapiens

Also known as PSA; SGPA; SRS4; ZNF912

Gene ID: 5324 | Gene type: protein coding

About PLAG1

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,160,909-56,211,273 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues, 29 paralogues and is associated with 82 phenotypes. Ubiquitous expression in ovary (RPKM 1.7), spleen (RPKM 1.3) and 23 other tissues.

Summary

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PLAG1 Products(3)

mRNA	Protein	Name
NM_001114634.2	NP_001108106.1	zinc finger protein PLAG1 isoform a
NM_001114635.2	NP_001108107.1	zinc finger protein PLAG1 isoform b
NM_002655.3	NP_002646.2	zinc finger protein PLAG1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10646861	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10646861	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10646861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAG1 Protein Structure

zf-H2C2_2

zf-C2H2

zf-H2C2_2

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

zinc finger protein PLAG1

COL1A2/PLAG1 fusion

Related Diseases

Diseases

Alias

Salivary Gland Adenoma, Pleomorphic

Salivary Gland Pleomorphic Adenoma	Sgpa
Psa	Adenomas, Salivary Gland Pleomorphic, Somatic
Benign Epithelial Tumor Of Salivary Glands	Pleomorphic Salivary Gland Adenoma
Pleomorphic Adenoma Of Salivary Gland	Adenomas, Salivary Gland Pleomorphic
Adenoma, Salivary Gland, Pleomorphic, Somatic

Silver-Russell Syndrome 4

SRS4

Silver-Russell Syndrome 1

Silver-Russell Syndrome	Russell-Silver Syndrome
Silver-Russell Dwarfism	Rss
SRS1	Srs
Silver Russell Dwarfism	Russell Silver Syndrome
Silver Russell Syndrome

Silver-Russell Syndrome Due To A Point Mutation

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Pleomorphic Adenoma

Mixed Tumor Of The Salivary Gland	Adenoma Pleomorphic
Adenoma, Pleomorphic	Mixed Salivary Gland Tumor
Mixed Tumor, Not Otherwise Specified

Hepatoblastoma

Lipoblastoma

Lipomatosis, Multiple

Lipoma	Familial Multiple Lipomatosis
Lipomatosis, Familial Multiple	Benign Lipomatous Tumor
Lipomatous Neoplasm	Multiple Lipomatosis
Fml	Lipo
Benign Tumor Of Adipose Tissue	Lipomatous Tumor
Tumor Of Adipose Tissue	Neoplasms, Adipose Tissue
Lipomas

Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma

Myoepithelioma

Benign Myoepithelioma	Myoepithelial Adenoma
Myoepithelial Neoplasm	Malignant Myoepithelioma

Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma	Adenomyo-Epithelioma
Clear Cell Carcinoma	Emc
Epithelial Myoepithelial Carcinoma	Glycogen-Rich Adenocarcinoma
Glycogen-Rich Adenoma	Monomorphic Clear Cell Tumor
Tubular Solid Adenoma	Adenocarcinoma, Clear Cell

Vulvar Leiomyoma

Vulvar Benign Neoplasm

Salivary Gland Carcinoma

Salivary Gland Cancer	Malignant Neoplasm Of Salivary Gland
Salivary Gland Neoplasms

Conventional Lipoma

Classic Type Lipoma

Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma

Parachordoma

Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland	Sweat Gland Tumor
Tumor Of The Sweat Gland	Sweat Gland Neoplasms
Sweat Gland Neoplasm

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland	Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland
Malignant Mixed Neoplasm Of Lacrimal Gland

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Breast Myoepithelial Neoplasm

Breast Myoepithelial Tumor

Malignant Breast Myoepithelioma

Breast Adenomyoepithelioma

Adenomyoepithelioma Of The Breast	Breast Adenomyoepithelioma With Malignant Change
Malignant Adenomyoepithelioma Of Breast

Apocrine Adenoma

Tubular Apocrine Adenoma

Gastrointestinal System Benign Neoplasm

Syringoma

Syringomas

Pseudoxanthoma Elasticum

PXE	Gronblad-Strandberg Syndrome
Pseudoxanthoma Elasticum, Modifier Of Severity Of	Gronblad-Strandberg-Touraine Syndrome
Gronblad Strandberg Syndrome	Groenblad-Strandberg Syndrome
Nevus Elasticus	Pxe - [Pseudoxanthoma Elasticum]

Spindle Cell Lipoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Sweat Gland Disease

Sweat Gland Diseases

Mulchandani-Bhoj-Conlin Syndrome

MBCS	Maternal Uniparental Disomy Of Chromosome 20
Maternal Upd(20)	Upd(20)Mat
Uniparental Disomy, Maternal, Chromosome 20

Necrotizing Sialometaplasia

Sialometaplasia, Necrotizing

Myxoid Leiomyosarcoma

Leiomyosarcoma, Myxoid

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Tonsil Cancer

Tonsillar Neoplasms	Malignant Neoplasm Of Faucial Tonsil
Malignant Neoplasm Of Palatine Tonsil	Malignant Neoplasm Of Tonsil, Faucial
Malignant Tonsillar Tumor	Malignant Tumor Of Tonsil
Tonsillar Carcinoma	Malignant Neoplasm Tonsil

Vulvar Sarcoma

Sarcoma Of Vulva

Vulva Sarcoma

Breast Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Breast

Mucoepidermoid Carcinoma Of The Breast

Chondroid Lipoma

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2	CISS2
Sweating Syndrome, Cold-Induced, Type 2

Oropharynx Cancer

Oropharyngeal Cancer	Oropharyngeal Carcinoma
Malignant Neoplasm Of Oropharynx	Malignant Oropharyngeal Tumor
Malignant Tumor Of Oropharynx	Malignant Tumour Of Mesopharynx
Oropharyngeal Cancer, Adult	Cancer Of The Oropharynx

Skin Benign Neoplasm

Neoplasm Of Skin By Site	Tumor Of The Skin
Skin Tumor	Benign Neoplasm Of Skin
Skin Neoplasms

Mixed Cell Type Cancer

Malignant Mixed Neoplasm	Malignant Mixed Tumor
Mixed Neoplasm	Mixed Tumor, Malignant
Malignant Mixed Cancer	Mixed Tumor
Malignant Mixed Tumor, Not Otherwise Specified	Mixed Salivary Gland Tumor
Mixed Tumor, Not Otherwise Specified

Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14	Temple Syndrome Due To Paternal 14q32.2 Microdeletion
Paternal Del(14)(Q32.2)	Temple Syndrome Due To Paternal 14q32.2 Hypomethylation
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Upd(14)Mat

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10643	PLAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLAG1	VGNC	VGNC:32971
Felis catus	PLAG1	VGNC	VGNC:68887
Mus musculus	PLAG1	MGD	MGI:1891916
Rattus norvegicus	PLAG1	RGD	RGD:1305286
Canis familiaris	PLAG1	VGNC	VGNC:44638