PLAGL2 - PLAG1 like zinc finger 2 Gene

Homo sapiens

Also known as ZNF900

Gene ID: 5326 | Gene type: protein coding

About PLAGL2

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,192,504-32,207,743 (from NCBI)

This gene has 1 transcript (splice variant), 285 orthologues and 29 paralogues. Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues.

Summary

Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

PLAGL2 Products(1)

mRNA	Protein	Name
NM_002657.3	NP_002648.1	zinc finger protein PLAGL2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15361364	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15361364	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAGL2 Protein Structure

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

zf-C2H2_4

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

zinc finger protein PLAGL2

C2H2-type zinc finger protein

PLAGL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLAGL2	Q9UPG8	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pleomorphic Adenoma

Mixed Tumor Of The Salivary Gland	Adenoma Pleomorphic
Adenoma, Pleomorphic	Mixed Salivary Gland Tumor
Mixed Tumor, Not Otherwise Specified

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Cataract 30

Cataract 30 Pulverulent	Cataract Coppock-Like
Ctrct30	Dusty Cataract
Cataract, Type 30

Gastrointestinal System Benign Neoplasm

Developmental And Epileptic Encephalopathy 1

Epileptic Encephalopathy, Early Infantile, 1	Infantile Epileptic-Dyskinetic Encephalopathy
DEE1	Eiee1
Issx1	Xmesid
X-Linked Infantile Spasm Syndrome 1	X-Linked Infantile Spasm Syndrome
X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome	Developmental And Epileptic Encephalopathy, 1
Infantile Epileptic Dyskinetic Encephalopathy	Infantile Spasm Syndrome, X-Linked 1
West Syndrome, X-Linked	Ohtahara Syndrome, X-Linked
Early Infantile Epileptic Encephalopathy 1	Early Infantile Epileptic Encephalopathy-1
Issx	X-Linked Ohtahara Syndrome
X-Linked West Syndrome	Infantile Spasm Syndrome X-Linked 1
Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity	Ohtahara Syndrome X-Linked
West Syndrome X-Linked	Encephalopathy, Epileptic, Early Infantile, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10645	PLAGL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLAGL2	VGNC	VGNC:68889
Macaca mulatta	PLAGL2	VGNC	VGNC:76160
Canis familiaris	PLAGL2	VGNC	VGNC:44640
Bos taurus	PLAGL2	VGNC	VGNC:32973
Rattus norvegicus	PLAGL2	RGD	RGD:1307999
Mus musculus	PLAGL2	MGD	MGI:1933165

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