2. Gene
  3. PTOV1 - PTOV1 extended AT-hook containing adaptor protein Gene

PTOV1 - PTOV1 extended AT-hook containing adaptor protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACID2; PTOV-1

Gene ID: 53635 | Gene type: protein coding

About PTOV1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,850,705-49,860,742 (from NCBI)

This gene has 21 transcripts (splice variants), 86 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 29.1), adrenal (RPKM 28.7) and 25 other tissues.

Summary

This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

PTOV1 Products(9)

mRNA Protein Name
NM_001305105.2 NP_001292034.1 prostate tumor-overexpressed gene 1 protein isoform 1
NM_001305108.2 NP_001292037.1 prostate tumor-overexpressed gene 1 protein isoform 2
NM_001364745.2 NP_001351674.1 prostate tumor-overexpressed gene 1 protein isoform 3
NM_001364747.2 NP_001351676.1 prostate tumor-overexpressed gene 1 protein isoform 4
NM_001364748.2 NP_001351677.1 prostate tumor-overexpressed gene 1 protein isoform 5
NM_001364749.2 NP_001351678.1 prostate tumor-overexpressed gene 1 protein isoform 4
NM_001364750.2 NP_001351679.1 prostate tumor-overexpressed gene 1 protein isoform 5
NM_001394010.1 NP_001380939.1 prostate tumor-overexpressed gene 1 protein isoform 1
NM_017432.5 NP_059128.2 prostate tumor-overexpressed gene 1 protein isoform 1

PTOV1 Protein Structure

Med25

Med25: Mediator complex subunit 25 PTOV activation and synapsin 2 (86 - 238)

Med25

Med25: Mediator complex subunit 25 PTOV activation and synapsin 2 (251 - 399)

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  • 416 a.a.
Protein Preferred Names Protein Names

prostate tumor-overexpressed gene 1 protein

activator interaction domain-containing protein 2

Related Diseases

Diseases Alias
Generalized Atherosclerosis

Generalised Atherosclerosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11408 PTOV1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PTOV1 RGD RGD:1306977
Bos taurus PTOV1 VGNC VGNC:33522
Macaca mulatta PTOV1 VGNC VGNC:76595
Canis familiaris PTOV1 VGNC VGNC:45161
Mus musculus PTOV1 MGD MGI:1933946
Felis catus PTOV1 VGNC VGNC:69155