PNOC - prepronociceptin Gene

Homo sapiens

Also known as NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ

Gene ID: 5368 | Gene type: protein coding

About PNOC

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,316,988-28,343,351 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 2 paralogues. Biased expression in brain (RPKM 7.7), lymph node (RPKM 5.0) and 8 other tissues.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

PNOC Products(2)

mRNA	Protein	Name
NM_001284244.2	NP_001271173.1	prepronociceptin isoform 2
NM_006228.5	NP_006219.1	prepronociceptin isoform 1 preproprotein

PNOC Protein Structure

Opiods_neuropep

0
100
176 a.a.

Protein Preferred Names

Protein Names

prepronociceptin

nociceptin

Related Diseases

Diseases

Alias

Postpartum Depression

Maternity Blues	Postnatal Depression
Depression, Postpartum	Post-Partum Depression
Depression Postpartum

Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn

Drug Dependence

Cluster Headache

Headache, Cluster

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Fibromyalgia

Diffuse Myofascial Pain Syndrome	Fibromyalgia Syndrome
Fibromyalgia-Fibromyositis Syndrome	Fibromyositis
Fibrositis	Fms
Myofascial Pain Syndrome	Myofascial Pain Syndromes

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Pain Agnosia

Analgesia

Opioid Abuse

Opioid-Related Disorders

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism

Opiate Dependence

Opioid Dependence	Opioid Addiction
Opiate Addiction	Opioid Type Dependence
Opioid-Related Disorders	Opium Dependence
Narcotic Dependence	Intravenous Narcotism
Narcotism Nos	Oral Narcotism Nos

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Specific Developmental Disorder

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10788	PNOC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PNOC	VGNC	VGNC:76200
Bos taurus	PNOC	VGNC	VGNC:33089
Mus musculus	PNOC	MGD	MGI:105308
Felis catus	PNOC	VGNC	VGNC:68932
Rattus norvegicus	PNOC	RGD	RGD:3362
Canis familiaris	PNOC	VGNC	VGNC:44750

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