IL20RA - interleukin 20 receptor subunit alpha Gene

Homo sapiens

Also known as CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha

Gene ID: 53832 | Gene type: protein coding

About IL20RA

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:136,999,971-137,044,965 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 11 paralogues. Biased expression in skin (RPKM 13.8), adrenal (RPKM 3.9) and 13 other tissues.

Summary

This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

IL20RA Products(4)

mRNA	Protein	Name
NM_001278722.2	NP_001265651.2	interleukin-20 receptor subunit alpha isoform 2
NM_001278723.3	NP_001265652.2	interleukin-20 receptor subunit alpha isoform 3
NM_001278724.4	NP_001265653.2	interleukin-20 receptor subunit alpha isoform 4
NM_014432.4	NP_055247.4	interleukin-20 receptor subunit alpha isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22802649	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL20RA Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

interleukin-20 receptor subunit alpha

class II cytokine receptor ZCYTOR7

IL20RA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL20RA	Q9UHF4	Q9NYY1-PRO_0000015381	Homo sapiens	Q9NYY1-PRO_0000015381	Crosslink	22802649
Intra	IL20RA	Q9UHF4	Q9NYY1-PRO_0000015381	Homo sapiens	Q9NYY1-PRO_0000015381	SPR	22802649
Intra	IL20RA	Q9UHF4	Q9NYY1-PRO_0000015381	Homo sapiens	Q9NYY1-PRO_0000015381	X-Ray Diffraction	22802649

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL20RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72562	IL-20R alpha Protein, Human (HEK293, His)	Q9UHF4-1 (V30-K250)	≥95%
HY-P77419	IL-20R alpha Protein, Human (HEK293, Fc)	Q9UHF4-1 (V30-K250)	≥95%

Related Diseases

Diseases

Alias

Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06732	IL20RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL20RA	VGNC	VGNC:67772
Rattus norvegicus	IL20RA	RGD	RGD:1307335
Bos taurus	IL20RA	VGNC	VGNC:30139
Macaca mulatta	IL20RA	VGNC	VGNC:73724
Canis familiaris	IL20RA	VGNC	VGNC:41965
Mus musculus	IL20RA	MGD	MGI:3605069

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