SLCO1C1 - solute carrier organic anion transporter family member 1C1 Gene

Homo sapiens

Also known as OATP1; OATPF; OATP-F; OATP14; OATP1C1; OATPRP5; SLC21A14

Gene ID: 53919 | Gene type: protein coding

About SLCO1C1

Cytogenetic location: 12p12.2 Genomic coordinates (GRCh38): 12:20,695,332-20,753,386 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues and 10 paralogues. Biased expression in brain (RPKM 4.0), fat (RPKM 0.5) and 3 other tissues.

Summary

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid Hormones in brain tissues. This protein has particularly high affinity for the thyroid Hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

SLCO1C1 Products(4)

mRNA	Protein	Name
NM_001145944.2	NP_001139416.1	solute carrier organic anion transporter family member 1C1 isoform 4
NM_001145945.2	NP_001139417.1	solute carrier organic anion transporter family member 1C1 isoform 3
NM_001145946.2	NP_001139418.1	solute carrier organic anion transporter family member 1C1 isoform 1
NM_017435.5	NP_059131.1	solute carrier organic anion transporter family member 1C1 isoform 2

SLCO1C1 Protein Structure

OATP

Kazal_2

0
200
400
600
712 a.a.

Protein Preferred Names

Protein Names

solute carrier organic anion transporter family member 1C1

OAT-RP-5

Related Diseases

Diseases

Alias

Allan-Herndon-Dudley Syndrome

AHDS	Allan-Herndon Syndrome
Monocarboxylate Transporter 8 Deficiency	MCT8 DEFICIENCY
Mental Retardation, X-Linked, With Hypotonia	Triiodothyronine Resistance
T3 Resistance	Mental Retardation And Muscular Atrophy
Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency	Intellectual Disability And Muscular Atrophy
Monocarboxylate Transporter-8 Deficiency	T3 Resisitence
Triiodothyronine Resistence	X-Linked Intellectual Disability With Hypotonia
Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency	Monocarboxylate Transporter 8 Deficiency
X-Linked Intellectual Disability-Hypotonia Syndrome

Deafness, Autosomal Recessive 62

DFNB62	Autosomal Recessive Nonsyndromic Deafness 62
Autosomal Recessive Deafness 62

Hyperthyroidism

Overactive Thyroid

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13354	SLCO1C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLCO1C1	VGNC	VGNC:46494
Macaca mulatta	SLCO1C1	VGNC	VGNC:77697
Felis catus	SLCO1C1	VGNC	VGNC:65443
Rattus norvegicus	SLCO1C1	RGD	RGD:628660
Mus musculus	SLCO1C1	MGD	MGI:1889679
Bos taurus	SLCO1C1	VGNC	VGNC:34950

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