Rgs8 - regulator of G-protein signaling 8 Gene

Rattus norvegicus

Gene ID: 54297 | Gene type: protein coding

About Rgs8

Primary_assembly 13: 65,804,797-65,846,807 forward strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 199 orthologues, 22 paralogues and is associated with 5 phenotypes. Restricted expression toward (RPKM 151.5).

Summary

Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and response to amphetamine. Located in dendrite; neuronal cell body membrane; and nucleus. Is extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Apr 2022]

Rgs8 Products(1)

mRNA	Protein	Name
NM_019344.3	NP_062217.1	regulator of G-protein signaling 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	9394004	RGD
enables GTPase activator activity	IDA IDA: Inferred from direct assay	9394004	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	9394004	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	9394004	RGD
involved in regulation of dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	9394004	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	26321241	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	12880183	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12880183	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	12880183	RGD
located in nucleus	IDA IDA: Inferred from direct assay	12880183	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rgs8 Protein Structure

RGS_RGS8

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13509	CCG-50014	Inhibitor	99.42%	Unkown
HY-U00431	CCG 203769	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgs8	NCBI	NCBI:85397

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