RGS8 - regulator of G protein signaling 8 Gene

Homo sapiens

Gene ID: 85397 | Gene type: protein coding

About RGS8

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:182,641,818-182,752,376 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and 23 paralogues. Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues.

Summary

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

RGS8 Products(9)

mRNA	Protein	Name
NM_001387849.1	NP_001374778.1	regulator of G-protein signaling 8 isoform 2
NM_033345.4	NP_203131.1	regulator of G-protein signaling 8 isoform 1
NM_001387847.1	NP_001374776.1	regulator of G-protein signaling 8 isoform 2
NM_001369564.2	NP_001356493.1	regulator of G-protein signaling 8 isoform 2
XM_017002631.3	XP_016858120.1	regulator of G-protein signaling 8 isoform X1
NM_001102450.3	NP_001095920.1	regulator of G-protein signaling 8 isoform 2
XM_011510089.4	XP_011508391.1	regulator of G-protein signaling 8 isoform X1
XM_047432939.1	XP_047288895.1	regulator of G-protein signaling 8 isoform X2
NM_001387848.1	NP_001374777.1	regulator of G-protein signaling 8 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	18434541	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	18434541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS8 Protein Structure

RGS

0
100
180 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 8

regulator of G-protein signalling 8

RGS8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGS8	P57771	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	RGS8	P57771	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1	SCA1
Olivopontocerebellar Atrophy I	Opca1
Opca4	Menzel Type Opca
Schut-Haymaker Type Opca	Spinocerebellar Atrophy I
Opca I	Olivopontocerebellar Atrophy Iv
Opca Iv	Cerebelloparenchymal Disorder I
Cpd1	Olivopontocerebellar Atrophy 1
Cerebelloparenchymal Disorder 1	Olivopontocerebellar Atrophy 4
Spinocerebellar Atrophy 1	Type 1 Spinocerebellar Ataxia
Spinocerebellar Ataxia-1	Ataxia, Spinocerebellar, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13509	CCG-50014	Inhibitor	99.42%	Unkown
HY-U00431	CCG 203769	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RGS8	MGD	MGI:108408
Canis familiaris	RGS8	VGNC	VGNC:45538
Rattus norvegicus	RGS8	RGD	RGD:3571
Felis catus	RGS8	VGNC	VGNC:107933
Bos taurus	RGS8	VGNC	VGNC:33925
Macaca mulatta	RGS8	VGNC	VGNC:100057

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