WNT4 - Wnt family member 4 Gene

Homo sapiens

Also known as WNT-4; SERKAL

Gene ID: 54361 | Gene type: protein coding

About WNT4

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,117,313-22,143,097 (from NCBI)

This gene has 3 transcripts (splice variants), 216 orthologues, 18 paralogues and is associated with 6 phenotypes. Biased expression in skin (RPKM 8.0), ovary (RPKM 4.5) and 13 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

WNT4 Products(1)

mRNA	Protein	Name
NM_030761.5	NP_110388.2	protein Wnt-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables receptor ligand activity	IDA IDA: Inferred from direct assay	16959810	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	12844346	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15317892	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	15040835	GOA
involved in epithelial to mesenchymal transition	IEP IEP: Inferred from expression pattern	12841867	GOA
involved in female sex determination	IMP IMP: Inferred from mutant phenotype	11283799	GOA
involved in kidney development	IEP IEP: Inferred from expression pattern	15312687	GOA
involved in liver development	IEP IEP: Inferred from expression pattern	15312687	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	17848411	GOA
involved in male gonad development	IMP IMP: Inferred from mutant phenotype	11283799	GOA
involved in mammary gland epithelium development	IEP IEP: Inferred from expression pattern	8168088	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12949260	GOA
involved in negative regulation of androgen biosynthetic process	IDA IDA: Inferred from direct assay	16959810	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	15317892	GOA
involved in negative regulation of male gonad development	IMP IMP: Inferred from mutant phenotype	11283799	GOA
involved in negative regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	15317892	GOA
involved in negative regulation of testicular blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	12949260	GOA
involved in negative regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	12949260	GOA
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17720811	GOA
involved in paramesonephric duct development	IMP IMP: Inferred from mutant phenotype	18182450	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16959810	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	17720811	GOA
involved in positive regulation of aldosterone biosynthetic process	IDA IDA: Inferred from direct assay	16981135	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	17720811	GOA
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	17720811	GOA
involved in positive regulation of cortisol biosynthetic process	IDA IDA: Inferred from direct assay	16981135	GOA
involved in positive regulation of dermatome development	IDA IDA: Inferred from direct assay	10654605	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	17720811	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16959810	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	16959810	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT4 Protein Structure

wnt

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

protein Wnt-4

wingless-type MMTV integration site family, member 4

Recombinant WNT4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700313	Wnt4 protein, Human (HEK293, C-hFc)	P56705-1 (S23-R351)	≥95%

Related Diseases

Diseases

Alias

46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs

Serkal Syndrome	SERKAL
Sex Reversion-Kidneys, Adrenal And Lung Dysgenesis Syndrome	Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs

Mullerian Aplasia And Hyperandrogenism

Mullerian Duct Failure And Hyperandrogenism	Wnt4 Deficiency
Müllerian Aplasia And Hyperandrogenism	Biason-Lauber Syndrome
Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome	Mayer-Rokitansky-Küster-Hauser-Like Syndrome
Müllerian Duct Failure	Wnt4 Müllerian Aplasia
Wnt4 Müllerian Aplasia And Ovarian Dysfunction	MULLAPL
Wnt4 Mullerian Aplasia And Ovarian Dysfunction

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Amenorrhea

Absence Of Menstruation

Amenia

Mayer-Rokitansky-Kuster-Hauser Syndrome

Mrkh Syndrome	Rokitansky Syndrome
Mullerian Aplasia	Mrkh Anomaly
Congenital Absence Of Uterus And Vagina	Congenital Absence Of The Uterus And Vagina
Genital Renal Ear Syndrome	Mayer-Rokitansky-Küster-Hauser Syndrome
Mullerian Dysgenesis	Müllerian Agenesis
Rokitansky Kuster Hauser Syndrome	MRKH
Mullerian Aplasia/Dysgenesis	Von Mayer-Rokitansky-Kuster Anomaly
Mrk Anomaly	Uterus Bipartitus Solidus Rudimentarius Cum Vagina Solida
Cauv	Mullerian Agenesis
Aplasia Of The Mullerian Ducts	Mullerian Duct Failure
Müllerian Aplasia	Rokitansky-Kuster-Hauser Syndrome
RKH SYNDROME

46,Xx Sex Reversal

46,Xx Testicular Disorder Of Sex Development	46,Xx Testicular Dsd
De La Chapelle Syndrome	Srxx
Xx, Male Syndrome	46, Xx Testicular Disorders Of Sex Development

Hyperandrogenism

Hyperandrogenization Syndrome

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies

Murcs Association	Mayer-Rokitansky-Kuster-Hauser Syndrome Type 2
Mrkh Syndrome Type 2	Mayer-Rokitansky-Küster-Hauser Syndrome Type 2
MURCS	Klippel-Feil Deformity, Conductive Deafness, And Absent Vagina
Atypical Mrkh Syndrome	Mullerian Duct Aplasia-Renal Dysplasia-Cervical Somite Anomalies Syndrome
Mayer-Rokitansky-Kuster-Hauser Syndrome, Type Ii	Mrkh, Type Ii
Mullerian Duct Aplasia, Unilateral Renal Aplasia, And Cervicothoracic Somite Dysplasia	Klippel-Feil Deformity - Conductive Deafness - Absent Vagina
Müllerian Aplasia - Renal Aplasia - Cervicothoracic Somite Dysplasia

Hermaphroditism

46,Xy Sex Reversal 2

Dosage-Sensitive Sex Reversal	Dss
SRXY2	46,Xy Sex Reversal, Dax1-Related
46xy Sex Reversal 2, Dosage-Sensitive	46,Xy Sex Reversal Dax1-Related

Submucous Uterine Fibroid

Submucous Leiomyoma Of Uterus

Renal Hypoplasia

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Osteoporosis-Pseudoglioma Syndrome

OPPG	Ops
Osteoporosis With Pseudoglioma	Osteogenesis Imperfecta, Ocular Form
Ocular Form Of Osteogenesis Imperfecta	Osteogenesis Imperfecta Ocular Form
Osteoporosis Pseudoglioma Syndrome	Pseudoglioma With Bone Fragility

Ovarian Serous Cystadenofibroma

Persistent Mullerian Duct Syndrome

Persistent Müllerian Duct Syndrome	Pmds
Persistent Oviduct Syndrome	Persistent Muellerian Duct Syndrome
Female Genital Ducts In Otherwise Normal Male	Hernia Uteri Inguinale
Persistent Mullerian Duct Syndrome, Types 1 And 2	Persistent Mullerian Derivatives

Ovarian Gonadoblastoma

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Ovarian Serous Adenofibroma

Pseudohermaphroditism

Indeterminate Sex And Pseudohermaphroditism

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15836	WNT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WNT4	VGNC	VGNC:106530
Bos taurus	WNT4	VGNC	VGNC:36959
Rattus norvegicus	WNT4	RGD	RGD:621348
Felis catus	WNT4	VGNC	VGNC:107690
Canis familiaris	WNT4	VGNC	VGNC:48424
Mus musculus	WNT4	MGD	MGI:98957
Others	WNT4	NCBI