SLC38A2 - solute carrier family 38 member 2 Gene

Homo sapiens

Also known as ATA2; SAT2; SNAT2; PRO1068

Gene ID: 54407 | Gene type: protein coding

About SLC38A2

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:46,358,188-46,372,773 (from NCBI)

This gene has 14 transcripts (splice variants), 260 orthologues and 15 paralogues. Ubiquitous expression in skin (RPKM 105.3), liver (RPKM 101.3) and 25 other tissues.

Summary

Enables neutral amino acid:sodium symporter activity. Involved in several processes, including amino acid transport; cellular response to arsenite(3-); and positive regulation of RNA splicing. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC38A2 Products(2)

mRNA	Protein	Name
NM_001307936.2	NP_001294865.1	sodium-coupled neutral amino acid symporter 2 isoform 2 precursor
NM_018976.5	NP_061849.2	sodium-coupled neutral amino acid symporter 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	16621798	GOA
enables amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15922329	GOA
enables amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	15774260	GOA
enables neutral L-amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	10930503	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25759021	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amino acid transmembrane transport	IMP IMP: Inferred from mutant phenotype	10930503	GOA
involved in amino acid transport	IDA IDA: Inferred from direct assay	15774260	GOA
involved in amino acid transport	IMP IMP: Inferred from mutant phenotype	15922329	GOA
involved in cellular response to arsenite(3-)	IMP IMP: Inferred from mutant phenotype	22215663	GOA
involved in neutral amino acid transport	IDA IDA: Inferred from direct assay	10930503	GOA
involved in positive regulation of RNA splicing	IPI IPI: Inferred from physical interaction	22215663	GOA
involved in positive regulation of gene expression	IPI IPI: Inferred from physical interaction	22215663	GOA
involved in regulation of cellular response to stress	IMP IMP: Inferred from mutant phenotype	22215663	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15581851	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15581851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC38A2 Protein Structure

Aa_trans

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

sodium-coupled neutral amino acid symporter 2

sodium-coupled neutral amino acid transporter 2

amino acid transporter 2

SLC38A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC38A2	Q96QD8	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	SLC38A2	Q96QD8	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	SLC38A2	Q96QD8	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	SLC38A2	Q96QD8	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC38A2	Q96QD8	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Adult Syndrome

Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome	Acro Dermato Ungual Lacrimal Tooth Syndrome
Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome
Adult

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13220	SLC38A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC38A2	RGD	RGD:69420
Bos taurus	SLC38A2	VGNC	VGNC:34849
Canis familiaris	SLC38A2	VGNC	VGNC:46393
Felis catus	SLC38A2	VGNC	VGNC:65345
Macaca mulatta	SLC38A2	VGNC	VGNC:77469
Mus musculus	SLC38A2	MGD	MGI:1915010
Others	SLC38A2	NCBI

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