2. Gene
  3. Cldn6 - claudin 6 Gene

Cldn6 - claudin 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 54419 | Gene type: protein coding

About Cldn6

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. [provided by RefSeq, Aug 2010]

Cldn6 Products(2)

mRNA Protein Name
NM_001414014.1 NP_001400943.1 claudin-6 precursor
NM_018777.5 NP_061247.1 claudin-6 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10601346 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell-cell junction organization IDA
IDA: Inferred from direct assay
17130295 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9892664 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9892664 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12060405 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-6

skullin

tight junction molecule claudin 6

Recombinant Cldn6 Proteins

Cat. No. Product Name Accession Purity
HY-P700692 Claudin-6/CLDN6 Protein-VLP, Mouse (HEK293) Q9Z262 (M1-V219) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99413 IMAB027 Inhibitor 95.00% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02774 CLDN6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990369 Anti-CLDN6 Antibody (AB3-7) Inhibitor / Unkown
HY-P990368 Anti-CLDN6 Antibody (AB1-11) Inhibitor / Unkown
HY-P990371 Anti-CLDN6 Antibody (IM-301) Inhibitor / Unkown
HY-P990579 Anti-CLDN6 Antibody (DS-9606A antibody) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn6 NCBI NCBI:9074
Macaca fascicularis Cldn6 NCBI NCBI:102140361