CLDN6 - claudin 6 Gene

Homo sapiens

Gene ID: 9074 | Gene type: protein coding

About CLDN6

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,014,712-3,018,183 (from NCBI)

This gene has 3 transcripts (splice variants), 76 orthologues and 22 paralogues. Low expression observed in reference dataset.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

CLDN6 Products(1)

mRNA	Protein	Name
NM_021195.5	NP_067018.2	claudin-6 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20375010	GOA
enables virus receptor activity	IMP IMP: Inferred from mutant phenotype	20375010	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20375010	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN6 Protein Structure

PMP22_Claudin

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

claudin-6

skullin

Recombinant CLDN6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77899	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, solution)	P56747 (M1-V220)	≥95%
HY-P77900	Claudin-6/CLDN6 Protein-VLP, Human (Biotinylated, HEK293)	P56747 (M1-V220)	≥95%
HY-P700406	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, His)	P56747 (M1-V220)	/

Related Diseases

Diseases

Alias

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Lymphoplasmacyte-Rich Meningioma

Lymphoplasmocyte-Rich Meningioma

Meningioma

Large Cell Medulloblastoma

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02774	CLDN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLDN6	VGNC	VGNC:80560
Macaca mulatta	CLDN6	VGNC	VGNC:71251
Rattus norvegicus	CLDN6	RGD	RGD:1308837
Bos taurus	CLDN6	VGNC	VGNC:27418
Canis familiaris	CLDN6	VGNC	VGNC:39322
Mus musculus	CLDN6	MGD	MGI:1859284
Macaca fascicularis	CLDN6	NCBI	NCBI:102140361
Others	CLDN6	NCBI

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