ANLN - anillin, actin binding protein Gene

Homo sapiens

Also known as scra; FSGS8; Scraps

Gene ID: 54443 | Gene type: protein coding

About ANLN

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,389,862-36,453,791 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 30.2), bone marrow (RPKM 11.3) and 11 other tissues.

Summary

This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

ANLN Products(3)

mRNA	Protein	Name
NM_001284301.3	NP_001271230.1	anillin isoform 2
NM_001284302.3	NP_001271231.1	anillin isoform 3
NM_018685.5	NP_061155.2	anillin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	10931866	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mitotic cytokinesis	IDA IDA: Inferred from direct assay	10931866	GOA
involved in podocyte cell migration	IMP IMP: Inferred from mutant phenotype	24676636	GOA
involved in positive regulation of bleb assembly	IMP IMP: Inferred from mutant phenotype	23870127	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10931866	GOA
located in actomyosin contractile ring	IDA IDA: Inferred from direct assay	10931866	GOA
located in bleb	IDA IDA: Inferred from direct assay	23870127	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	23870127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANLN Protein Structure

Anillin

0
200
400
600
800
1000
1124 a.a.

Protein Preferred Names

Protein Names

anillin

Related Diseases

Diseases

Alias

Focal Segmental Glomerulosclerosis 8

FSGS8	Glomerulosclerosis, Focal Segmental, 8
Glomerulosclerosis, Focal Segmental, Type 8

Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Genetic Srns
Hereditary Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Nephrotic Syndrome
Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive	Srn1

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Spinocerebellar Ataxia 44

SCA44

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00739	ANLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANLN	VGNC	VGNC:37922
Felis catus	ANLN	VGNC	VGNC:59826
Bos taurus	ANLN	VGNC	VGNC:25950
Rattus norvegicus	ANLN	RGD	RGD:1561367
Mus musculus	ANLN	MGD	MGI:1920174
Macaca mulatta	ANLN	VGNC	VGNC:69610

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