Asah2 - N-acylsphingosine amidohydrolase 2 Gene

Mus musculus

Gene ID: 54447 | Gene type: protein coding

About Asah2

Summary

Enables N-acylsphingosine amidohydrolase activity. Involved in lipid digestion and sphingolipid metabolic process. Located in caveola; extracellular space; and mitochondrion. Is integral component of plasma membrane. Orthologous to several human genes including ASAH2B (N-acylsphingosine amidohydrolase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Asah2 Products(1)

mRNA	Protein	Name
NM_018830.1	NP_061300.1	neutral ceramidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acylsphingosine amidohydrolase activity	IDA IDA: Inferred from direct assay	10652340	MGI
enables N-acylsphingosine amidohydrolase activity	IMP IMP: Inferred from mutant phenotype	21613224	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12921776	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	21613224	MGI
involved in ceramide catabolic process	IDA IDA: Inferred from direct assay	10652340	MGI
involved in ceramide catabolic process	IMP IMP: Inferred from mutant phenotype	16126722	MGI
involved in lipid digestion	IMP IMP: Inferred from mutant phenotype	16380386	MGI
involved in sphingosine biosynthetic process	IDA IDA: Inferred from direct assay	10652340	MGI
involved in sphingosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	16126722	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	12921776	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	16126722	MGI
located in membrane	IDA IDA: Inferred from direct assay	10753931	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	21613224	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12921776	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neutral ceramidase

N-CDase	NCDase
acylsphingosine deacylase 2	neutral/alkaline ceramidase

Recombinant Asah2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76735	ASAH2 Protein, Mouse (HEK293, His)	Q9JHE3/NP_061300.1 (T34-T756)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01054	ASAH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asah2	NCBI	NCBI:56624

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