PON3 - paraoxonase 3 Gene

Homo sapiens

Gene ID: 5446 | Gene type: protein coding

About PON3

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,359,872-95,396,375 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 130.3) and ovary (RPKM 7.4).

Summary

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the Other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]

PON3 Products(1)

mRNA	Protein	Name
NM_000940.3	NP_000931.1	serum paraoxonase/lactonase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acyl-L-homoserine-lactone lactonohydrolase activity	IDA IDA: Inferred from direct assay	15772423	GOA
enables arylesterase activity	IDA IDA: Inferred from direct assay	15772423	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	15772423	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in carboxylic acid catabolic process	IDA IDA: Inferred from direct assay	15772423	GOA
involved in lactone catabolic process	IDA IDA: Inferred from direct assay	15772423	GOA
involved in regulation of cellular response to drug	IDA IDA: Inferred from direct assay	15772423	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PON3 Protein Structure

Arylesterase

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

serum paraoxonase/lactonase 3

arylesterase 3

Recombinant PON3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74623	PON3 Protein, Human (S50N, sf9, His)	Q15166-1 (M1-L354)	≥95%

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Acute Tympanitis

Acute Myringitis

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Persian Gulf Syndrome

Gulf War Syndrome

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Coronary Heart Disease 1

Coronary Heart Disease	Coronary Heart Disease, Susceptibility To, 1
Chds1	Coronary Heart Disease, Susceptibility To
CHD	Heart, Coronary, Disease, Susceptibility To, Type 1
Coronary Arteriosclerosis	Coronary Artery Disease

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10874	PON3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PON3	MGD	MGI:106686
Felis catus	PON3	VGNC	VGNC:68959
Rattus norvegicus	PON3	RGD	RGD:1302965
Bos taurus	PON3	VGNC	VGNC:33162
Canis familiaris	PON3	VGNC	VGNC:44814
Macaca mulatta	PON3	VGNC	VGNC:76221
Others	PON3	NCBI

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