ETAA1 - ETAA1 activator of ATR kinase Gene

Homo sapiens

Also known as ETAA16

Gene ID: 54465 | Gene type: protein coding

About ETAA1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:67,397,333-67,412,089 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 6.6), endometrium (RPKM 6.0) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activator activity. Involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of DNA damage checkpoint; and replication fork processing. Located in cytosol; nuclear replication fork; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ETAA1 Products(1)

mRNA	Protein	Name
NM_019002.4	NP_061875.2	ewing's tumor-associated antigen 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27723717	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	27723717	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	27723717	GOA
involved in mitotic G2/M transition checkpoint	IDA IDA: Inferred from direct assay	30139873	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	27723717	GOA
involved in regulation of DNA damage checkpoint	IDA IDA: Inferred from direct assay	27723717	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	27723717	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear replication fork	IDA IDA: Inferred from direct assay	27723717	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETAA1 Protein Structure

ETAA1

0
200
400
600
800
926 a.a.

Protein Preferred Names

Protein Names

ewing's tumor-associated antigen 1

ETAA1, ATR kinase activator

ETAA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83036	ETAA1 Antibody (YA2781)	WB	Human

Related Diseases

Diseases

Alias

Immunodeficiency 26

Severe Combined Immunodeficiency Due To Dna-Pkcs Deficiency	Scid Due To Dna-Pkcs Deficiency
Imd26	Immunodeficiency 26, With Or Without Neurologic Abnormalities

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04550	ETAA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ETAA1	RGD	RGD:1587340
Macaca mulatta	ETAA1	VGNC	VGNC:106157
Bos taurus	ETAA1	VGNC	VGNC:28616
Canis familiaris	ETAA1	VGNC	VGNC:40486
Felis catus	ETAA1	VGNC	VGNC:61974
Mus musculus	ETAA1	MGD	MGI:1915395

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