NLE1 - notchless homolog 1 Gene

Homo sapiens

Also known as NLE

Gene ID: 54475 | Gene type: protein coding

About NLE1

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 6.4), ovary (RPKM 4.9) and 25 other tissues.

Summary

Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NLE1 Products(2)

mRNA	Protein	Name
NM_001014445.2	NP_001014445.1	notchless protein homolog 1 isoform b
NM_018096.5	NP_060566.2	notchless protein homolog 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLE1 Protein Structure

NLE

WD40

0
100
200
300
400
485 a.a.

Protein Preferred Names

Protein Names

notchless protein homolog 1

Notchless gene homolog

Related Diseases

Diseases

Alias

Pasteurellosis

Pasteurella Infection	Pasteurella Infections
Pasteurella Infectious Disease	Shipping Fever
Transport Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09338	NLE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NLE1	VGNC	VGNC:32109
Canis familiaris	NLE1	VGNC	VGNC:43838
Felis catus	NLE1	VGNC	VGNC:63820
Macaca mulatta	NLE1	VGNC	VGNC:75217
Rattus norvegicus	NLE1	RGD	RGD:1308301
Mus musculus	NLE1	MGD	MGI:2429770

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