Dll4 - delta like canonical Notch ligand 4 Gene

Mus musculus

Also known as Delta4

Gene ID: 54485 | Gene type: protein coding

About Dll4

Summary

Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2022]

Dll4 Products(1)

mRNA	Protein	Name
NM_019454.3	NP_062327.2	delta-like protein 4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Notch binding	IDA IDA: Inferred from direct assay	10837024	MGI
enables Notch binding	IPI IPI: Inferred from physical interaction	20947685	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16000382	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	24667410	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in T cell differentiation	IDA IDA: Inferred from direct assay	15146182	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in blood vessel lumenization	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in cardiac atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in dorsal aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	26114479	MGI
acts upstream of or within negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	18559979	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in pericardium morphogenesis	IMP IMP: Inferred from mutant phenotype	15466159	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	26114479	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	22323600	MGI
involved in regulation of neural retina development	IMP IMP: Inferred from mutant phenotype	22323600	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	19389377	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	15466159	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

delta-like protein 4

delta-like 4

drosophila Delta homolog 4

Recombinant Dll4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75292	Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His)	Q9JI71 (S28-P525)	≥95%
HY-P75293	Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc)	Q9JI71 (S28-P525)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99377	Navicixizumab	Inhibitor	/	Phase 3
HY-P99852	Dilpacimab	Inhibitor	/	Phase 2
HY-P99925	Enoticumab	Inhibitor	99.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122094	Steppogenin	Inhibitor	99.49%	Unkown
HY-RS03810	DLL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99261	Demcizumab	Inhibitor	≥95.0%	Unkown
HY-P991033	Tovecimig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dll4	NCBI	NCBI:54567
Macaca mulatta	Dll4	NCBI	NCBI:704898

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