PCDH18 - protocadherin 18 Gene

Homo sapiens

Also known as PCDH68L

Gene ID: 54510 | Gene type: protein coding

About PCDH18

Cytogenetic location: 4q28.3 Genomic coordinates (GRCh38): 4:137,518,918-137,532,494 (from NCBI)

This gene has 8 transcripts (splice variants), 274 orthologues and 61 paralogues. Broad expression in placenta (RPKM 18.1), endometrium (RPKM 17.7) and 21 other tissues.

Summary

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical Cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]

PCDH18 Products(2)

mRNA	Protein	Name
NM_001300828.2	NP_001287757.1	protocadherin-18 isoform 2 precursor
NM_019035.5	NP_061908.1	protocadherin-18 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCDH18 Protein Structure

Cadherin_2

Cadherin

0
200
400
600
800
1000
1135 a.a.

Protein Preferred Names

Protein Names

protocadherin-18

protocadherin 68-like protein

PCDH18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCDH18	Q9HCL0	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	PCDH18	Q9HCL0	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	PCDH18	Q9HCL0	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10127	PCDH18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCDH18	RGD	RGD:1305870
Bos taurus	PCDH18	VGNC	VGNC:32619
Canis familiaris	PCDH18	VGNC	VGNC:44296
Macaca mulatta	PCDH18	VGNC	VGNC:75600
Mus musculus	PCDH18	MGD	MGI:1920423
Felis catus	PCDH18	VGNC	VGNC:64061

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