POU2F2 - POU class 2 homeobox 2 Gene

Homo sapiens

Also known as OCT2; OTF2; Oct-2

Gene ID: 5452 | Gene type: protein coding

About POU2F2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,086,110-42,197,936 (from NCBI)

This gene has 21 transcripts (splice variants), 261 orthologues and 17 paralogues. Broad expression in lymph node (RPKM 11.8), spleen (RPKM 7.4) and 14 other tissues.

Summary

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

POU2F2 Products(10)

mRNA	Protein	Name
NM_001207025.4	NP_001193954.1	POU domain, class 2, transcription factor 2 isoform 1
NM_001207026.3	NP_001193955.1	POU domain, class 2, transcription factor 2 isoform 3
NM_001247994.3	NP_001234923.1	POU domain, class 2, transcription factor 2 isoform 4
NM_001393934.1	NP_001380863.1	POU domain, class 2, transcription factor 2 isoform 5
NM_001393935.1	NP_001380864.1	POU domain, class 2, transcription factor 2 isoform 6
NM_001393936.1	NP_001380865.1	POU domain, class 2, transcription factor 2 isoform 7
NM_001394376.1	NP_001381305.1	POU domain, class 2, transcription factor 2 isoform 8
NM_001394377.1	NP_001381306.1	POU domain, class 2, transcription factor 2 isoform 9
NM_001394378.1	NP_001381307.1	POU domain, class 2, transcription factor 2 isoform 10
NM_002698.6	NP_002689.1	POU domain, class 2, transcription factor 2 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9242494	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9242494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU2F2 Protein Structure

Pou

Homeobox

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

POU domain, class 2, transcription factor 2

homeobox protein

Related Diseases

Diseases

Alias

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Papilloma

Papillomatosis

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10898	POU2F2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POU2F2	VGNC	VGNC:59358
Rattus norvegicus	POU2F2	RGD	RGD:621690
Felis catus	POU2F2	VGNC	VGNC:68965
Mus musculus	POU2F2	MGD	MGI:101897
Canis familiaris	POU2F2	VGNC	VGNC:44827

Name
Email *

	Sorry, but the email address you supplied was invalid.