2. Gene
  3. POU2F2 - POU class 2 homeobox 2 Gene

POU2F2 - POU class 2 homeobox 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OCT2; OTF2; Oct-2

Gene ID: 5452 | Gene type: protein coding

About POU2F2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,086,110-42,197,936 (from NCBI)

This gene has 21 transcripts (splice variants), 261 orthologues and 17 paralogues. Broad expression in lymph node (RPKM 11.8), spleen (RPKM 7.4) and 14 other tissues.

Summary

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

POU2F2 Products(10)

mRNA Protein Name
NM_001207025.4 NP_001193954.1 POU domain, class 2, transcription factor 2 isoform 1
NM_001207026.3 NP_001193955.1 POU domain, class 2, transcription factor 2 isoform 3
NM_001247994.3 NP_001234923.1 POU domain, class 2, transcription factor 2 isoform 4
NM_001393934.1 NP_001380863.1 POU domain, class 2, transcription factor 2 isoform 5
NM_001393935.1 NP_001380864.1 POU domain, class 2, transcription factor 2 isoform 6
NM_001393936.1 NP_001380865.1 POU domain, class 2, transcription factor 2 isoform 7
NM_001394376.1 NP_001381305.1 POU domain, class 2, transcription factor 2 isoform 8
NM_001394377.1 NP_001381306.1 POU domain, class 2, transcription factor 2 isoform 9
NM_001394378.1 NP_001381307.1 POU domain, class 2, transcription factor 2 isoform 10
NM_002698.6 NP_002689.1 POU domain, class 2, transcription factor 2 isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9242494 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
9242494 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU2F2 Protein Structure

Pou

Pou: Pou domain - N-terminal to homeobox domain (196 - 269)

Homeobox

Homeobox: Homeobox domain (298 - 354)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

POU domain, class 2, transcription factor 2

homeobox protein

Related Diseases

Diseases Alias
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
Papilloma

Papillomatosis
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10898 POU2F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus POU2F2 VGNC VGNC:59358
Rattus norvegicus POU2F2 RGD RGD:621690
Felis catus POU2F2 VGNC VGNC:68965
Mus musculus POU2F2 MGD MGI:101897
Canis familiaris POU2F2 VGNC VGNC:44827