1. Gene
  2. ROBO4 - roundabout guidance receptor 4 Gene

ROBO4 - roundabout guidance receptor 4 Gene

Homo sapiens

Also known as MRB; AOVD3; ECSM4

Gene ID: 54538 | Gene type: protein coding

About ROBO4

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,883,691-124,897,865 (from NCBI)

This gene has 10 transcripts (splice variants), 99 orthologues, 36 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 35.9), spleen (RPKM 32.4) and 17 other tissues.

Summary

Predicted to enable cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. [provided by Alliance of Genome Resources, Apr 2022]

ROBO4 Products(2)

mRNA Protein Name
NM_001301088.2 NP_001288017.1 roundabout homolog 4 isoform 2
NM_019055.6 NP_061928.4 roundabout homolog 4 isoform 1 precursor

ROBO4 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (32 - 124)

I-set

I-set: Immunoglobulin I-set domain (138 - 220)

fn3

fn3: Fibronectin type III domain (350 - 432)

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  • 1007 a.a.
Protein Preferred Names Protein Names

roundabout homolog 4

roundabout homolog 4, magic roundabout

Recombinant ROBO4 Proteins

Cat. No. Product Name Accession Purity
HY-P71262 ROBO4 Protein, Human (HEK293, Fc) Q8WZ75-1 (Q28-R467) ≥95%
HY-P76009 ROBO4 Protein, Human (HEK293, His) Q8WZ75-1 (Q28-R467) ≥95%

Related Diseases

Diseases Alias
Aortic Valve Disease 3

AOVD3

Aortic Valve Disease 1

Aortic Valve Disease

Bicuspid Aortic Valve

Aortic Valve Disorder

AOVD1

Bav

Bicuspid Aortic Valve Disease

Familial Bicuspid Aortic Valve

Aortic Valve Calcification

Aovd

Aortic Valve, Bicuspid

Aortic Valve, Calcification Of

Aortic Stenosis, Calcific

Familial Bav

Calcific Aortic Stenosis

Calcification Of Aortic Valve

Abnormality Of The Aortic Valve

Aortic Valve Disease, Type 1

Aortic Valve Disease 2

Bicommissural Aortic Valve

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Aortic Aneurysm

Aortic Rupture

Thoracoabdominal Aortic Aneurysm, Ruptured

Ruptured Aortic Aneurysm

Aortic Aneurysms

Aortic Aneurysm Without Mention Of Rupture Nos

Ruptured Abdominal Aortic Aneurysm

Aortic Aneurysm, Ruptured

Ruptured Thoracic Aortic Aneurysm

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta

Corneal Neovascularization

Corneal Neovascularisation

Corneal Vascularisation

Extensive Superficial Corneal Vascularisation

Hypoplastic Left Heart Syndrome

Hlhs

Heart, Hypoplastic Left, Syndrome

Hypoplasia Of The Left Heart

Left Heart Hypoplasia Syndrome

Hlhs - [Hypoplastic Left Heart Syndrome]

Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome

Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome

Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle

Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia

Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome

Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

MLC2A

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation

Hantavirus Pulmonary Syndrome

Hps

Four Corners Hantavirus

Hards

Hantavirus

Hantavirus-Associated Respiratory Distress Syndrome

Hanta Virus

Hantavirus Cardiopulmonary Syndrome

Hps - [Hantavirus Pulmonary Syndrome]

Hcps - [Hantavirus Cardiopulmonary Syndrome]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus ROBO4 VGNC VGNC:34081
Rattus norvegicus ROBO4 RGD RGD:6494870
Mus musculus ROBO4 MGD MGI:1921394
Canis familiaris ROBO4 VGNC VGNC:45687
Macaca mulatta ROBO4 VGNC VGNC:76760
Felis catus ROBO4 VGNC VGNC:81954
Others ROBO4 NCBI