POU3F3 - POU class 3 homeobox 3 Gene

Homo sapiens

Also known as BRN1; OTF8; oct-8; SNIBFIS; brain-1

Gene ID: 5455 | Gene type: protein coding

About POU3F3

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:104,854,115-104,858,574 (from NCBI)

This gene has 2 transcripts (splice variants), 86 orthologues, 17 paralogues and is associated with 2 phenotypes.

Summary

This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]

POU3F3 Products(1)

mRNA	Protein	Name
NM_006236.3	NP_006227.1	POU domain, class 3, transcription factor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	31303265	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	31303265	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	31303265	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU3F3 Protein Structure

Pou

Homeobox

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

POU domain, class 3, transcription factor 3

brain-specific homeobox/POU domain protein 1

Related Diseases

Diseases

Alias

Snijders Blok-Fisher Syndrome

SNIBFIS

Esophagus Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma	Oesophagus Squamous Cell Carcinoma
Scc Of Esophagus	Scc Of Oesophagus
Squamous Cell Carcinoma Of The Esophagus	Escc
Esophageal Epidermoid Carcinoma	Squamous Cell Esophageal Cancer
Squamous Cell Carcinoma Of Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10902	POU3F3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POU3F3	VGNC	VGNC:106872
Mus musculus	POU3F3	MGD	MGI:102564
Rattus norvegicus	POU3F3	RGD	RGD:619768

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