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  2. PARP14 - poly(ADP-ribose) polymerase family member 14 Gene

PARP14 - poly(ADP-ribose) polymerase family member 14 Gene

Homo sapiens

Also known as BAL2; ARTD8; pART8; PARP-14

Gene ID: 54625 | Gene type: protein coding

About PARP14

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,680,839-122,730,840 (from NCBI)

This gene has 7 transcripts (splice variants), 295 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues.

Summary

This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of Cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

PARP14 Products(3)

mRNA Protein Name
NM_017554.3 NP_060024.2 protein mono-ADP-ribosyltransferase PARP14
XM_011512929.3 XP_011511231.1 protein mono-ADP-ribosyltransferase PARP14 isoform X1
XR_007095695.1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NAD+ binding IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
18851833 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
27796300 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
27796300 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23473667 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in positive regulation of interleukin-4-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in protein poly-ADP-ribosylation IMP
IMP: Inferred from mutant phenotype
16061477 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27796300 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP14 Protein Structure

Macro

Macro: Macro domain (820 - 936)

Macro

Macro: Macro domain (1044 - 1147)

Macro

Macro: Macro domain (1245 - 1346)

WWE

WWE: WWE domain (1536 - 1586)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (1625 - 1800)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1801 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP14

ADP-ribosyltransferase diphtheria toxin-like 8

B-aggressive lymphoma 2

b aggressive lymphoma protein 2

collaborator of STAT6

poly [ADP-ribose] polymerase 14

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 44

SCA44

Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta PARP14 VGNC VGNC:84054
Felis catus PARP14 VGNC VGNC:102797
Mus musculus PARP14 MGD MGI:1919489
Rattus norvegicus PARP14 RGD RGD:1310490
Canis familiaris PARP14 VGNC VGNC:53082
Others PARP14 NCBI