CROT - carnitine O-octanoyltransferase Gene

Homo sapiens

Also known as COT

Gene ID: 54677 | Gene type: protein coding

About CROT

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:87,345,664-87,399,794 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 12.0), urinary bladder (RPKM 8.5) and 22 other tissues.

Summary

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

CROT Products(3)

mRNA	Protein	Name
NM_001143935.2	NP_001137407.1	peroxisomal carnitine O-octanoyltransferase isoform 1
NM_001243745.3	NP_001230674.1	peroxisomal carnitine O-octanoyltransferase isoform 3
NM_021151.4	NP_066974.2	peroxisomal carnitine O-octanoyltransferase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carnitine O-octanoyltransferase activity	IDA IDA: Inferred from direct assay	10486279	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	21619872	GOA
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	21619872	GOA
involved in generation of precursor metabolites and energy	IDA IDA: Inferred from direct assay	10486279	GOA
involved in medium-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	10486279	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisome	IDA IDA: Inferred from direct assay	21619872	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CROT Protein Structure

Carn_acyltransf

0
100
200
300
400
500
612 a.a.

Protein Preferred Names

Protein Names

peroxisomal carnitine O-octanoyltransferase

peroxisomal carnitine acyltransferase

Recombinant CROT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74218	CROT Protein, Human (V474L, sf9, His)	Q9UKG9-1 (M1-L612, V474L)	≥95%

Related Diseases

Diseases

Alias

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03194	CROT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CROT	VGNC	VGNC:27723
Rattus norvegicus	CROT	RGD	RGD:70908
Felis catus	CROT	VGNC	VGNC:61188
Macaca mulatta	CROT	VGNC	VGNC:71495
Mus musculus	CROT	MGD	MGI:1921364
Canis familiaris	CROT	VGNC	VGNC:39627
Others	CROT	NCBI

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