DCHS2 - dachsous cadherin-related 2 Gene

Homo sapiens

Also known as CDHJ; CDH27; CDHR7; PCDHJ; PCDH23

Gene ID: 54798 | Gene type: protein coding

About DCHS2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,231,742-154,491,799 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 70 orthologues and 33 paralogues. Broad expression in stomach (RPKM 1.1), testis (RPKM 0.9) and 16 other tissues.

Summary

This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017]

DCHS2 Products(3)

mRNA	Protein	Name
NM_001142552.2	NP_001136024.1	protocadherin-23 isoform 2
NM_001358235.2	NP_001345164.1	protocadherin-23 isoform 3
NM_001412223.1	NP_001399152.1	protocadherin-23 isoform 4

DCHS2 Protein Structure

Cadherin

0
500
1000
1500
2000
2500
2916 a.a.

Protein Preferred Names

Protein Names

protocadherin-23

cadherin J

Related Diseases

Diseases

Alias

Van Maldergem Syndrome

Van Maldergem Wetzburger Verloes Syndrome	Cerebro-Facio-Articular Syndrome
Cerebro-Facio-Articular Syndrome Of Van Maldergem	Cerebrofacioarticular Syndrome
Cerebro Facio Articular Syndrome	Van Maldergem-Wetzburger-Verloes Syndrome

Adult Pineal Parenchymal Tumor

Adult Pineal Parenchymal Neoplasm

Adult Pineoblastoma

Luminal Breast Carcinoma B

Luminal B Breast Carcinoma

Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma

Hennekam Syndrome

Hennekam Lymphangiectasia Lymphedema Syndrome	Hennekam Lymphangiectasia-Lymphedema Syndrome
Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome	Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome
Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome	Lymphangiectasies And Lymphedema Hennekam Type
Generalized Lymphatic Dysplasia	Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03576	DCHS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DCHS2	RGD	RGD:1563329
Felis catus	DCHS2	VGNC	VGNC:78479
Mus musculus	DCHS2	MGD	MGI:2685263
Macaca mulatta	DCHS2	VGNC	VGNC:100217

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