TRPM7 - transient receptor potential cation channel subfamily M member 7 Gene

Homo sapiens

Also known as CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK

Gene ID: 54822 | Gene type: protein coding

About TRPM7

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:50,557,158-50,686,797 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 8.4), kidney (RPKM 8.2) and 25 other tissues.

Summary

This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

TRPM7 Products(2)

mRNA	Protein	Name
NM_001301212.2	NP_001288141.1	transient receptor potential cation channel subfamily M member 7 isoform b
NM_017672.6	NP_060142.3	transient receptor potential cation channel subfamily M member 7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	11385574	GOA
enables magnesium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	35561741	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16636202	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15485879	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	11385574	GOA
involved in magnesium ion homeostasis	IDA IDA: Inferred from direct assay	12887921	GOA
involved in magnesium ion transport	IDA IDA: Inferred from direct assay	35561741	GOA
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	24316671	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18365021	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18365021	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	35561741	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPM7 Protein Structure

Ion_trans

Alpha_kinase

0
300
600
900
1200
1500
1865 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 7

LTRPC ion channel family member 7

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1

Guam Disease	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam
Als-Pdc	Lytico-Bodig Disease
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome	Parkinsonism-Dementia-Als Complex
Pdals	Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam
Parkinson-Dementia Complex Of Guam	G-Pdc
Guam Parkinsonism-Dementia Complex	ALS-PDC1
Als/Pdc Of Guam	Amyotrophic Lateral Sclerosis
Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1	Amyotrophic Lateral Sclerosis, Guam Form
Parkinsonian Disorders

Hypomagnesemia 1, Intestinal

Intestinal Hypomagnesemia 1	HOMG1
Hypomagnesemia With Secondary Hypocalcemia	Hsh
Hypomagnesemic Tetany	Intestinal Hypomagnesemia With Secondary Hypocalcemia
Homg	Hypomagnesemia Caused By Selective Magnesium Malabsorption
Hypomagnesemia Intestinal Type 1	Primary Hypomagnesemia With Secondary Hypocalcemia
Phsh	Hypomagnesemia, Intestinal, With Secondary Hypocalcemia
Familial Primary Hypomagnesemia With Hypocalcuria	Hypomagnesemia 1
Hypomagnesmic Tetany

Autosomal Dominant Macrothrombocytopenia

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Trigeminal Neuralgia

Tic Douloureux	Trifacial Neuralgia
Trifocal Neuralgia	Neuralgia Of The Fifth Cranial Nerve
Neuralgia Of 5th Cranial Nerve	Infraorbital Neuralgia

Cardiomyopathy, Dilated, 1o

Dilated Cardiomyopathy 1o	CMD1O
Dilated Cardiomyopathy With Ventricular Tachycardia	Cardiomyopathy, Dilated, With Ventricular Tachycardia
Cardiomyopathy, Dilated 1o	Cardiomyopathy, Dilated, Type 1o

Dystonia 26, Myoclonic

Myoclonic Dystonia 26

DYT26

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN	X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
Cid Due To Magt1 Deficiency	Combined Immunodeficiency Due To Magt1 Deficiency
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An	X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia

Aplasia Of Lacrimal And Salivary Glands

ALSG	Congenital Absence Of Lacrimal Puncta And Salivary Glands
Xerostomia	Absence Of Salivary Glands
Parotid Aplasia Or Hypoplasia	Congenital Absence Of Lacrimal Puncta Or Salivary Glands
Alsg - [Aplasia Of Lacrimal Or Salivary Glands]

Progressive Familial Heart Block

Hereditary Bundle Branch Defect	Hereditary Bundle Branch System Defect
Familial Lenegre Disease	Familial Lev Disease
Familial Lev-Lenegre Disease	Familial Pccd
Familial Progressive Heart Block	Pfhb
Bundle Branch Block	Hbbd
Lenegre Lev Disease	Lev Syndrome
Lev'S Disease	Lev-Lenègre Disease
Pccd	Progressive Cardiac Conduction Defect
Bundle-Branch Block

Primary Hypomagnesemia

Familial Primary Hypomagnesemia	Homg
Primary Familial Hypomagnesemia	Genetic Primary Hypomagnesemia
Hypomagnesemia 1, Intestinal

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Mucolipidosis Iv

Mucolipidosis Type Iv	ML4
Sialolipidosis	Mucolipidosis Type 4
Ganglioside Sialidase Deficiency	Mliv
Ml Iv	Berman Syndrome
Ganglioside Neuraminidase Deficiency	Ml 4
Mucolipidosis 4	Type Iv Mucolipidosis
Gangliosidoses

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101302	Naltriben mesylate		99.65%	Unkown
HY-133717	Naltriben		/	Unkown
HY-149999	Xeniafaraunol A	Inhibitor	/	Unkown
HY-157227	VPC01091.4	Inhibitor	98.04%	Unkown
HY-160509	BTB 06061	Inhibitor	/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-RS15117	TRPM7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRPM7	VGNC	VGNC:66592
Bos taurus	TRPM7	VGNC	VGNC:36393
Macaca mulatta	TRPM7	VGNC	VGNC:79106
Rattus norvegicus	TRPM7	RGD	RGD:620053
Canis familiaris	TRPM7	VGNC	VGNC:47878
Mus musculus	TRPM7	MGD	MGI:1929996
Others	TRPM7	NCBI

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