CKMT1A - creatine kinase, mitochondrial 1A Gene

Homo sapiens

Also known as CKMT1; U-MtCK; mia-CK

Gene ID: 548596 | Gene type: protein coding

About CKMT1A

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,692,786-43,699,222 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 4 paralogues. Biased expression in colon (RPKM 49.4), duodenum (RPKM 46.7) and 12 other tissues.

Summary

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate Cancer cells via Apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

CKMT1A Products(5)

mRNA	Protein	Name
NM_001015001.2	NP_001015001.1	creatine kinase U-type, mitochondrial isoform 1 precursor
NM_001321926.2	NP_001308855.1	creatine kinase U-type, mitochondrial isoform 1 precursor
NM_001321927.1	NP_001308856.1	creatine kinase U-type, mitochondrial isoform 2
NM_001321928.1	NP_001308857.1	creatine kinase U-type, mitochondrial isoform 2
NM_001321929.1	NP_001308858.1	creatine kinase U-type, mitochondrial isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

creatine kinase U-type, mitochondrial

acidic-type mitochondrial creatine kinase

Recombinant CKMT1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76264	CKMT1A Protein, Human (sf9, His)	P12532 (A40-H417)	≥95%

Related Diseases

Diseases

Alias

Prostate Rhabdomyosarcoma

Rhabdomyosarcoma Of The Prostate

Mitochondrial Complex V Deficiency, Nuclear Type 3

Mitochondrial Complex Iii Deficiency Nuclear Type 5	MC5DN3
Mitochondrial Complex Iii Deficiency, Nuclear Type 5	Mitochondrial Complex V Deficiency Nuclear Type 3
MC3DN5	Mitochondrial Complex V Deficiency, Atp5e Type
Mitochondrial Complex Iii Deficiency, Nuclear 5	Mitochondrial Complex V Deficiency, Nuclear Type 3
Mitochondrial Complex V Deficiency Atp5e Type	Mitochondrial Complex V Deficiency Type 3
Mitochondrial Complex V Deficiency, Nuclear, Type 3

Dressler'S Syndrome

Dressler Syndrome	Postmyocardial Infarction Syndrome
Donath-Landsteiner Hemolytic Anemia	Post-Myocardial Infarction Syndrome
Postmyocardial Infarction Pericarditis

Cerebral Creatine Deficiency Syndrome

Deficiency, Cerebral Creatine, Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02739	CKMT1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CKMT1A	MGD	MGI:99441

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