2. Gene
  3. PXK - PX domain containing serine/threonine kinase like Gene

PXK - PX domain containing serine/threonine kinase like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLOB; MONAKA

Gene ID: 54899 | Gene type: protein coding

About PXK

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,332,892-58,426,127 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues.

Summary

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

PXK Products(58)

mRNA Protein Name
NM_001289095.2 NP_001276024.1 PX domain-containing protein kinase-like protein isoform b
NM_001289096.2 NP_001276025.1 PX domain-containing protein kinase-like protein isoform c
NM_001289098.2 NP_001276027.1 PX domain-containing protein kinase-like protein isoform d
NM_001289099.2 NP_001276028.1 PX domain-containing protein kinase-like protein isoform e
NM_001289100.2 NP_001276029.1 PX domain-containing protein kinase-like protein isoform f
NM_001289101.2 NP_001276030.1 PX domain-containing protein kinase-like protein isoform g
NM_001349488.2 NP_001336417.1 PX domain-containing protein kinase-like protein isoform d
NM_001349489.2 NP_001336418.1 PX domain-containing protein kinase-like protein isoform e
NM_001349490.2 NP_001336419.1 PX domain-containing protein kinase-like protein isoform f
NM_001349491.2 NP_001336420.1 PX domain-containing protein kinase-like protein isoform g
NM_001349492.2 NP_001336421.1 PX domain-containing protein kinase-like protein isoform h
NM_001349493.2 NP_001336422.1 PX domain-containing protein kinase-like protein isoform i
NM_001349494.2 NP_001336423.1 PX domain-containing protein kinase-like protein isoform j
NM_001349495.2 NP_001336424.1 PX domain-containing protein kinase-like protein isoform k
NM_001349496.2 NP_001336425.1 PX domain-containing protein kinase-like protein isoform jj
NM_001349497.2 NP_001336426.1 PX domain-containing protein kinase-like protein isoform l
NM_001349498.1 NP_001336427.1 PX domain-containing protein kinase-like protein isoform m
NM_001349499.2 NP_001336428.1 PX domain-containing protein kinase-like protein isoform n
NM_001349500.2 NP_001336429.1 PX domain-containing protein kinase-like protein isoform o
NM_001349501.2 NP_001336430.1 PX domain-containing protein kinase-like protein isoform p
NM_001349502.2 NP_001336431.1 PX domain-containing protein kinase-like protein isoform q
NM_001349503.2 NP_001336432.1 PX domain-containing protein kinase-like protein isoform r
NM_001349504.2 NP_001336433.1 PX domain-containing protein kinase-like protein isoform kk
NM_001349506.2 NP_001336435.1 PX domain-containing protein kinase-like protein isoform kk
NM_001349507.2 NP_001336436.1 PX domain-containing protein kinase-like protein isoform r
NM_001349508.2 NP_001336437.1 PX domain-containing protein kinase-like protein isoform s
NM_001349509.2 NP_001336438.1 PX domain-containing protein kinase-like protein isoform s
NM_001349510.2 NP_001336439.1 PX domain-containing protein kinase-like protein isoform t
NM_001349511.2 NP_001336440.1 PX domain-containing protein kinase-like protein isoform u
NM_001349512.2 NP_001336441.1 PX domain-containing protein kinase-like protein isoform ll
NM_001349513.2 NP_001336442.1 PX domain-containing protein kinase-like protein isoform mm
NM_001349514.2 NP_001336443.1 PX domain-containing protein kinase-like protein isoform nn
NM_001349515.2 NP_001336444.1 PX domain-containing protein kinase-like protein isoform v
NM_001349516.2 NP_001336445.1 PX domain-containing protein kinase-like protein isoform oo
NM_001349517.2 NP_001336446.1 PX domain-containing protein kinase-like protein isoform pp
NM_001349518.2 NP_001336447.1 PX domain-containing protein kinase-like protein isoform w
NM_001349519.2 NP_001336448.1 PX domain-containing protein kinase-like protein isoform x
NM_001349520.2 NP_001336449.1 PX domain-containing protein kinase-like protein isoform x
NM_001349521.2 NP_001336450.1 PX domain-containing protein kinase-like protein isoform qq
NM_001349522.2 NP_001336451.1 PX domain-containing protein kinase-like protein isoform y
NM_001349524.2 NP_001336453.1 PX domain-containing protein kinase-like protein isoform z
NM_001349525.2 NP_001336454.1 PX domain-containing protein kinase-like protein isoform aa
NM_001349526.2 NP_001336455.1 PX domain-containing protein kinase-like protein isoform bb
NM_001349527.2 NP_001336456.1 PX domain-containing protein kinase-like protein isoform cc
NM_001349528.2 NP_001336457.1 PX domain-containing protein kinase-like protein isoform dd
NM_001349529.2 NP_001336458.1 PX domain-containing protein kinase-like protein isoform dd
NM_001349530.2 NP_001336459.1 PX domain-containing protein kinase-like protein isoform ee
NM_001349531.2 NP_001336460.1 PX domain-containing protein kinase-like protein isoform rr
NM_001349532.2 NP_001336461.1 PX domain-containing protein kinase-like protein isoform ff
NM_001349533.2 NP_001336462.1 PX domain-containing protein kinase-like protein isoform gg
NM_001349534.2 NP_001336463.1 PX domain-containing protein kinase-like protein isoform gg
NM_001349535.2 NP_001336464.1 PX domain-containing protein kinase-like protein isoform hh
NM_001349536.2 NP_001336465.1 PX domain-containing protein kinase-like protein isoform hh
NM_001349537.2 NP_001336466.1 PX domain-containing protein kinase-like protein isoform ss
NM_001349538.2 NP_001336467.1 PX domain-containing protein kinase-like protein isoform ss
NM_001349539.2 NP_001336468.1 PX domain-containing protein kinase-like protein isoform ii
NM_001349540.2 NP_001336469.1 PX domain-containing protein kinase-like protein isoform ii
NM_017771.5 NP_060241.2 PX domain-containing protein kinase-like protein isoform a

PXK Protein Structure

PX

PX: PX domain (30 - 121)

Pkinase

Pkinase: Protein kinase domain (198 - 351)

WH2

WH2: WH2 motif (546 - 573)

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  • 578 a.a.
Protein Preferred Names Protein Names

PX domain-containing protein kinase-like protein

PX ser/thr kinase v2

Related Diseases

Diseases Alias
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11481 PXK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PXK VGNC VGNC:33583
Macaca mulatta PXK VGNC VGNC:76522
Rattus norvegicus PXK RGD RGD:727819
Felis catus PXK VGNC VGNC:64448
Mus musculus PXK MGD MGI:1289230
Canis familiaris PXK VGNC VGNC:45219
Others PXK NCBI