CMTM6 - CKLF like MARVEL transmembrane domain containing 6 Gene

Homo sapiens

Also known as CKLFSF6; PRO2219

Gene ID: 54918 | Gene type: protein coding

About CMTM6

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,481,312-32,502,852 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 14 paralogues. Ubiquitous expression in appendix (RPKM 47.3), thyroid (RPKM 44.1) and 25 other tissues.

Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CMTM6 Products(1)

mRNA	Protein	Name
NM_017801.3	NP_060271.1	CKLF-like MARVEL transmembrane domain-containing protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28813410	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	28813417	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	28813417	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	28813410	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	28813417	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	28813410	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	28813417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTM6 Protein Structure

MARVEL

0
100
183 a.a.

Protein Preferred Names

Protein Names

CKLF-like MARVEL transmembrane domain-containing protein 6

chemokine-like factor super family 6

CMTM6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CMTM6	Q9NX76	CD274	Homo sapiens	Q9NZQ7	Anti Bait CoIP	28813410
Intra	CMTM6	Q9NX76	CD274	Homo sapiens	Q9NZQ7	Confocal	28813417
Intra	CMTM6	Q9NX76	CD274	Homo sapiens	Q9NZQ7	Anti Bait CoIP	28813417
Intra	CMTM6	Q9NX76	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	CMTM6	Q9NX76	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	CMTM6	Q9NX76	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	CMTM6	Q9NX76	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02868	CMTM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CMTM6	MGD	MGI:2447165
Macaca mulatta	CMTM6	VGNC	VGNC:84199
Rattus norvegicus	CMTM6	RGD	RGD:1307765
Canis familiaris	CMTM6	VGNC	VGNC:39383
Bos taurus	CMTM6	VGNC	VGNC:27486
Felis catus	CMTM6	VGNC	VGNC:102677

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