RASIP1 - Ras interacting protein 1 Gene

Homo sapiens

Also known as RAIN

Gene ID: 54922 | Gene type: protein coding

About RASIP1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,720,585-48,740,610 (from NCBI)

This gene has 4 transcripts (splice variants), 188 orthologues and 1 paralogue. Broad expression in fat (RPKM 11.9), spleen (RPKM 8.9) and 23 other tissues.

Summary

Enables GTPase binding activity and protein homodimerization activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and positive regulation of Integrin activation. Located in cell-cell junction. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RASIP1 Products(1)

mRNA	Protein	Name
NM_017805.3	NP_060275.2	ras-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	26780829	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26780829	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26780829	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	26780829	GOA
involved in negative regulation of Rho-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	26780829	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in negative regulation of membrane permeability	IDA IDA: Inferred from direct assay	26780829	GOA
involved in positive regulation of integrin activation	IMP IMP: Inferred from mutant phenotype	26780829	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IMP IMP: Inferred from mutant phenotype	26780829	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26780829	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASIP1 Protein Structure

DIL

0
200
400
600
800
963 a.a.

Protein Preferred Names

Protein Names

ras-interacting protein 1

Related Diseases

Diseases

Alias

Enamel Erosion

Floating-Harbor Syndrome

FLHS	Fhs
Pelletier-Leisti Syndrome	Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes
Leisti-Hollander-Rimoin Syndrome

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Tooth Erosion

Generalized Erosion	Localized Erosion
Generalized Erosions	Erosion, Localized

Pseudo-Torch Syndrome 1

Pseudo-Torch Syndrome	Band-Like Calcification With Simplified Gyration And Polymicrogyria
Blcpmg	PTORCH1
Baraitser-Brett-Piesowicz Syndrome	Baraitser-Reardon Syndrome
Bilateral Band-Like Calcification With Polymicrogyria	Blc-Pmg
Microcephaly-Intracranial Calcification-Intellectual Disability Syndrome	Congenital Intrauterine Infection-Like Syndrome
Baraitser Brett Piesowicz Syndrome	Microcephaly - Intracranial Calcification - Intellectual Disability

Sotos Syndrome

Cerebral Gigantism	SOTOS
Chromosome 5q35 Deletion Syndrome	Sotos Syndrome 1, Formerly
Sotos1, Formerly	Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development
Sotos Sequence	Sotos' Syndrome
Sotos1	Sotos Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11697	RASIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RASIP1	VGNC	VGNC:33751
Mus musculus	RASIP1	MGD	MGI:1917153
Rattus norvegicus	RASIP1	RGD	RGD:1305291
Canis familiaris	RASIP1	VGNC	VGNC:45374

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