SLC35F6 - solute carrier family 35 member F6 Gene

Homo sapiens

Also known as ANT2BP; TANGO9; C2orf18

Gene ID: 54978 | Gene type: protein coding

About SLC35F6

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,764,284-26,781,231 (from NCBI)

This gene has 4 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in thyroid (RPKM 11.5), skin (RPKM 10.8) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including lysosomal membrane; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLC35F6 Products(1)

mRNA	Protein	Name
NM_017877.4	NP_060347.2	solute carrier family 35 member F6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19154410	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19154410	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19154410	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	20957757	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19154410	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35F6 Protein Structure

SLC35F

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

solute carrier family 35 member F6

ANT2-binding protein

Related Diseases

Diseases

Alias

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Gingival Fibromatosis

Hereditary Gingival Fibromatosis	Hereditary Gingival Hyperplasia
Autosomal Dominant Gingival Fibromatosis	Autosomal Dominant Gingival Hyperplasia
Fibromatosis, Gingival, Hereditary	Fibromatosis, Gingival

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13209	SLC35F6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC35F6	RGD	RGD:1309228
Macaca mulatta	SLC35F6	VGNC	VGNC:106219
Felis catus	SLC35F6	VGNC	VGNC:65336
Bos taurus	SLC35F6	VGNC	VGNC:34836
Canis familiaris	SLC35F6	VGNC	VGNC:46380
Mus musculus	SLC35F6	MGD	MGI:1922169

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