ZWILCH - zwilch kinetochore protein Gene

Homo sapiens

Also known as KNTC1AP; hZwilch

Gene ID: 55055 | Gene type: protein coding

About ZWILCH

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,505,326-66,550,130 (from NCBI)

This gene has 14 transcripts (splice variants) and 197 orthologues. Broad expression in testis (RPKM 32.5), lymph node (RPKM 6.0) and 19 other tissues.

Summary

Involved in protein localization to kinetochore. Located in kinetochore. Part of RZZ complex. [provided by Alliance of Genome Resources, Apr 2022]

ZWILCH Products(4)

mRNA	Protein	Name
NM_001287821.2	NP_001274750.1	protein zwilch homolog isoform 2
NM_001287822.2	NP_001274751.1	protein zwilch homolog isoform 2
NM_001287823.2	NP_001274752.1	protein zwilch homolog isoform 2
NM_017975.5	NP_060445.3	protein zwilch homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12686595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	15824131	GOA
involved in protein localization to kinetochore	IMP IMP: Inferred from mutant phenotype	15824131	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RZZ complex	IDA IDA: Inferred from direct assay	20462495	GOA
part of RZZ complex	IPI IPI: Inferred from physical interaction	25849506	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	12686595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZWILCH Protein Structure

Zwilch

0
100
200
300
400
500
591 a.a.

Protein Preferred Names

Protein Names

protein zwilch homolog

Zwilch, kinetochore associated, homolog

Related Diseases

Diseases

Alias

Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type	X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome
CDP-PBHM	Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16209	ZWILCH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZWILCH	RGD	RGD:1583880
Felis catus	ZWILCH	VGNC	VGNC:67389
Bos taurus	ZWILCH	VGNC	VGNC:37391
Macaca mulatta	ZWILCH	VGNC	VGNC:79496
Canis familiaris	ZWILCH	VGNC	VGNC:48865
Mus musculus	ZWILCH	MGD	MGI:1915264

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