SLC38A4 - solute carrier family 38 member 4 Gene

Homo sapiens

Also known as ATA3; NAT3; PAAT; SNAT4

Gene ID: 55089 | Gene type: protein coding

About SLC38A4

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:46,764,761-46,832,431 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues and 15 paralogues. Restricted expression toward liver (RPKM 138.1).

Summary

SLC38A4 is found predominantly in liver and transports both cationic and neutral Amino acids. The transport of cationic Amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral Amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]

SLC38A4 Products(2)

mRNA	Protein	Name
NM_001143824.2	NP_001137296.1	sodium-coupled neutral amino acid transporter 4
NM_018018.5	NP_060488.2	sodium-coupled neutral amino acid transporter 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alanine:sodium symporter activity	IDA IDA: Inferred from direct assay	11414754	GOA
enables amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	33928121	GOA
enables neutral L-amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	11342143	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-alanine import across plasma membrane	IDA IDA: Inferred from direct assay	11414754	GOA
involved in neutral amino acid transport	IDA IDA: Inferred from direct assay	11342143	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in microvillus membrane	IDA IDA: Inferred from direct assay	19015196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC38A4 Protein Structure

Aa_trans

0
100
200
300
400
500
547 a.a.

Protein Preferred Names

Protein Names

sodium-coupled neutral amino acid transporter 4

N amino acid transporter 3

SLC38A4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC38A4	Q969I6	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC38A4	Q969I6	GJA8	Homo sapiens	P48165	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mahvash Disease

Gcgr-Related Hyperglucagonemia	MVAH
Alpha-Cell Hyperplasia With Glucagonemia	Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor
Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor

Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30	CILD30
Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 30 Without Situs Inversus
Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 30

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13222	SLC38A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC38A4	MGD	MGI:1916604
Macaca mulatta	SLC38A4	VGNC	VGNC:77484
Felis catus	SLC38A4	VGNC	VGNC:65347
Bos taurus	SLC38A4	VGNC	VGNC:34851
Canis familiaris	SLC38A4	VGNC	VGNC:46395
Rattus norvegicus	SLC38A4	RGD	RGD:621836

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