PIWIL2 - piwi like RNA-mediated gene silencing 2 Gene

Homo sapiens

Also known as CT80; HILI; mili; PIWIL1L

Gene ID: 55124 | Gene type: protein coding

About PIWIL2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,275,316-22,357,568 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 3 paralogues. Biased expression in testis (RPKM 18.7), duodenum (RPKM 3.2) and 2 other tissues.

Summary

PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

PIWIL2 Products(3)

mRNA	Protein	Name
NM_001135721.3	NP_001129193.1	piwi-like protein 2 isoform 1
NM_001330480.2	NP_001317409.1	piwi-like protein 2 isoform 2
NM_018068.5	NP_060538.2	piwi-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables piRNA binding	IDA IDA: Inferred from direct assay	21193640	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28903391	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	28903391	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28025795	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28025795	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIWIL2 Protein Structure

PAZ

Piwi

0
200
400
600
800
973 a.a.

Protein Preferred Names

Protein Names

piwi-like protein 2

cancer/testis antigen 80

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10585	PIWIL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PIWIL2	VGNC	VGNC:44593
Macaca mulatta	PIWIL2	VGNC	VGNC:81502
Bos taurus	PIWIL2	VGNC	VGNC:32928
Felis catus	PIWIL2	VGNC	VGNC:79363
Mus musculus	PIWIL2	MGD	MGI:1930036
Rattus norvegicus	PIWIL2	RGD	RGD:1306964

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