2. Gene
  3. MRPS10 - mitochondrial ribosomal protein S10 Gene

MRPS10 - mitochondrial ribosomal protein S10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRP-S10; PNAS-122

Gene ID: 55173 | Gene type: protein coding

About MRPS10

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,206,807-42,217,861 (from NCBI)

This gene has 1 transcript (splice variant) and 203 orthologues. Ubiquitous expression in esophagus (RPKM 21.1), heart (RPKM 17.6) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]

MRPS10 Products(1)

mRNA Protein Name
NM_018141.4 NP_060611.2 28S ribosomal protein S10, mitochondrial
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
part of mitochondrial small ribosomal subunit IDA
IDA: Inferred from direct assay
25838379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS10 Protein Structure

Ribosomal_S10

Ribosomal_S10: Ribosomal protein S10p/S20e (78 - 173)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

28S ribosomal protein S10, mitochondrial

S10mt

Related Diseases

Diseases Alias
Plethora Of Newborn

Neonatal Polycythemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08674 MRPS10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MRPS10 MGD MGI:1928139
Felis catus MRPS10 VGNC VGNC:102466
Canis familiaris MRPS10 VGNC VGNC:43408
Rattus norvegicus MRPS10 RGD RGD:1311516
Bos taurus MRPS10 VGNC VGNC:31654